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首页> 外文期刊>Molecular and Cellular Biology >Cellular DNA region involved in induction of thymic lymphomas (Mlvi-2) maps to mouse chromosome 15.
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Cellular DNA region involved in induction of thymic lymphomas (Mlvi-2) maps to mouse chromosome 15.

机译：涉及胸腺淋巴瘤（Mlvi-2）诱导的细胞DNA区域映射到小鼠15号染色体。

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Two cellular DNA regions representing common domains for proviral DNA integration ( Mlvi -1 and Mlvi -2) have been identified in Moloney murine leukemia virus-induced rat thymic lymphomas. Cellular sequences which were free of repeated DNA derived from a clone that defines the Mlvi -2 integration domain (lambda Cl228 ) were found to be highly conserved in a variety of vertebrate species that we examined, including mice, hamsters, cats, and humans. In this study, we identified the chromosomal map location of the Mlvi -2 homologous sequences in mice by using hamster-mouse somatic cell hybrids. The results show that Mlvi -2 is present on mouse chromosome 15 but is unrelated to the c-myc and c-sis proto-oncogenes, which map on the same chromosome. Since aberrations on chromosome 15 have been observed reproducibly in mouse thymomas, our data suggest that Mlvi -2 may define a novel sequence involved in the induction or progression of murine thymic lymphomas.
机译：已经在莫洛尼氏鼠白血病病毒诱导的大鼠胸腺淋巴瘤中鉴定了代表前病毒DNA整合的共同结构域的两个细胞DNA区域（Mlvi -1和Mlvi -2）。发现在包含我们检查过的多种脊椎动物中，包括小鼠，仓鼠，猫和人，其细胞序列不含源自定义Mlvi -2整合域（λCl228）的克隆的重复DNA，是高度保守的。在这项研究中，我们通过使用仓鼠-小鼠体细胞杂种来鉴定小鼠中Mlvi -2同源序列的染色体图位置。结果表明，Mlvi -2存在于小鼠15号染色体上，但与c-myc和c-sis原癌基因无关，后者位于同一条染色体上。由于在小鼠胸腺瘤中可再现地观察到15号染色体上的畸变，因此我们的数据表明Mlvi -2可能定义了与鼠胸腺淋巴瘤的诱导或进展有关的新序列。

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