Active X chromosome DNA is unmethylated at eight CCGG sites clustered in a guanine-plus-cytosine-rich island at the 5' end of the gene for phosphoglycerate kinase.

D H Keith; J Singer-Sam; A D Riggs

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Active X chromosome DNA is unmethylated at eight CCGG sites clustered in a guanine-plus-cytosine-rich island at the 5' end of the gene for phosphoglycerate kinase.

机译：活跃的X染色体DNA在聚磷酸甘油酸激酶基因5'端的富含鸟嘌呤+胞嘧啶的岛中的八个CCGG位点未甲基化。

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The 5' control region and first exon for human X-chromosome-linked phosphoglycerate kinase is contained in a G + C-rich island. We measured methylation at all HpaII sites in this 5' region of leukocyte DNA. By use of a blotting procedure that allows analysis of small DNA fragments, we found that the HpaII sites are entirely methylated when from an inactive X chromosome and entirely unmethylated when from an active one. In contrast, methylation of HpaII sites in more downstream regions of the gene is essentially the same in active and inactive X chromosomes.

机译：人X染色体连接的磷酸甘油酸激酶的5'控制区和第一个外显子包含在富含G + C的岛中。我们在白细胞DNA的5'区域中的所有HpaII位点测量了甲基化。通过使用允许分析小的DNA片段的印迹程序，我们发现当HpaII位点来自无活性的X染色体时，它完全被甲基化，而当来自活性染色体时，则完全未被甲基化。相反，在基因的更下游区域中，HpaII位点的甲基化在活跃和不活跃的X染色体中基本相同。

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《Molecular and Cellular Biology》 |1986年第11期|共4页
作者
D H Keith; J Singer-Sam; A D Riggs;
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中图分类细胞生物学;
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1. Methylation-free site patterns along a 1-Mb locus on Chr19 in cancerous and normal cells are similar. A new fast approach for analyzing unmethylated CCGG sites distribution [J] . Azhikina T, Gainetdinov I, Skvortsova Y, Molecular biology reports . 2006,第6期

机译：在癌细胞和正常细胞中，沿Chr19上1-Mb位点的无甲基化位点模式相似。分析未甲基化CCGG位点分布的新快速方法
2. Methylation-free site patterns along a 1-Mb locus on Chr19 in cancerous and normal cells are similar. A new fast approach for analyzing unmethylated CCGG sites distribution [J] . Azhikina T, Gainetdinov I, Skvortsova Y, Molecular genetics and genomics: MGG . 2006,第6期

机译：在癌细胞和正常细胞中，沿Chr19上1-Mb位点的无甲基化位点模式相似。分析未甲基化CCGG位点分布的新快速方法
3. Methylation-free site patterns along a 1-Mb locus on Chr19 in cancerous and normal cells are similar. A new fast approach for analyzing unmethylated CCGG sites distribution [J] . Tatyana Azhikina, Ildar Gainetdinov, Yulia Skvortsova, Molecular Genetics and Genomics . 2006,第6期

机译：在癌细胞和正常细胞中，沿Chr19上1-Mb位点的无甲基化位点模式相似。一种分析未甲基化CCGG位点分布的快速新方法
4. Peopling, demographic history and genetic structure of the Azores Islands: Integrating data from mtDNAand Y-chromosome [C] . Cristina Santos, Rafael Montiel, Conceifao Bettencour International Society for Forensic Genetics . 2006

机译：亚塞尔群岛的人口统计学，人口统计历史和遗传结构：与Mtdnaand Y-染色体的数据集成
5. A single MEF-2 site Is a Major Positive Regulatory Element Required for Transcription of the Muscle-Specific Subunit of the Human Phosphoglycerate Mutase Gene in Skeletal and Cardiac Muscle Cells [D] . Nakatsuji, Yuji 1993

机译：一个MEF-2位点是骨骼肌和心肌细胞中人类磷酸甘油酸突变酶基因的肌肉特定亚基转录所需的主要正调控元件。
6. Active X chromosome DNA is unmethylated at eight CCGG sites clustered in a guanine-plus-cytosine-rich island at the 5 end of the gene for phosphoglycerate kinase. [O] . D H Keith, J Singer-Sam, A D Riggs 1986

机译：活跃的X染色体DNA在聚集在磷酸甘油酸激酶基因5端富含鸟嘌呤+胞嘧啶的岛上的八个CCGG位点未甲基化。
7. Active X chromosome DNA is unmethylated at eight CCGG sites clustered in a guanine-plus-cytosine-rich island at the 5' end of the gene for phosphoglycerate kinase. [O] . Keith, D H, Singer-Sam, J, Riggs, A D 1986

机译：活跃的X染色体DNA在聚集于磷酸甘油酸激酶基因5'端富含鸟嘌呤+胞嘧啶的岛上的八个CCGG位点未甲基化。

Active X chromosome DNA is unmethylated at eight CCGG sites clustered in a guanine-plus-cytosine-rich island at the 5' end of the gene for phosphoglycerate kinase.

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