Expression of c-sis and platelet-derived growth factor in in vitro-transformed glioma cells from rat brain tissue transplacentally treated with ethylnitrosourea.

P F Lens; B Altena; R Nusse

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Expression of c-sis and platelet-derived growth factor in in vitro-transformed glioma cells from rat brain tissue transplacentally treated with ethylnitrosourea.

机译：c-sis和血小板源性生长因子在乙基亚硝基脲经胎盘处理的大鼠脑组织体外转化的神经胶质瘤细胞中的表达。

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Long-term culturing of brain cells from neonatal BD-IX rats after transplacental treatment with N-ethyl-N-nitrosourea (ENU) results in malignantly transformed cells after a lag period of about 250 days. During culturing, the brain cells undergo a sequence of morphological changes. We examined oncogene expression in cultured cells from ENU-treated animals and found that transformed glioma cells differ from premalignant glial cells by containing high levels of c-sis transcripts. We also report that the transformed cells synthesize functional platelet-derived growth factor. Because glial cells have receptors for platelet-derived growth factor, we propose that an autocrine mechanism plays an important role in ENU-induced brain tumorigenesis.

机译：用N-乙基-N-亚硝基脲（ENU）经胎盘处理后，长期培养新生BD-IX大鼠脑细胞会导致约250天的滞后期恶变转化细胞。在培养过程中，脑细胞经历一系列形态变化。我们检查了来自ENU治疗的动物的培养细胞中的癌基因表达，发现转化的神经胶质瘤细胞与恶性神经胶质细胞不同，因为它含有高水平的c-sis转录物。我们还报告了转化细胞合成了功能性血小板衍生的生长因子。由于神经胶质细胞具有血小板衍生生长因子的受体，因此我们提出自分泌机制在ENU诱导的脑肿瘤发生中起重要作用。

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《Molecular and Cellular Biology》 |1986年第10期|共4页
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P F Lens; B Altena; R Nusse;
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中图分类细胞生物学;
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1. Platelet-derived growth factor BB mediates the glioma-induced migration of bone marrow-derived mesenchymal stem cells by promoting the expression of vascular cell adhesion molecule-1 through the PI3K, P38 MAPK and NF-κB pathways [J] . HuY., ChengP., Jiang-chunM., Oncology reports . 2013,第6期

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2. Effect of interleukin-10 and platelet-derived growth factor on expressions of matrix metalloproteinases-2 and tissue inhibitor of metalloproteinases-1 in rat fibrotic liver and cultured hepatic stellate cells [J] . Li-Juan Zhang, Yun-Xin Chen, Zhi-Xin Chen, World Journal of Gastroenterology . 2004,第17期

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3. Expression of β‐nerve growth factor mRNA in rat glioma cells and astrocytes from rat brain [J] . Amano Takehiko, Hishinuma Fumio, Kuwano Ryozo, FEBS Letters . 1987,第1期

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4. Micropreparative LC Fractionation for Differential Expression Analysis of Protein Extracts from Endothelial Cells Treated with Vascular Endothelial Growth Factors [C] . J. Flensburg, F. Bahram, L. Claesson-Welsh ASMS Conference on Mass Spectrometry and Allied Topics . 2008

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5. The role of platelet-derived growth factor (PDGF) signaling in gliomagenesis. [D] . Dai, Chengkai. 2003

机译：血小板源性生长因子（PDGF）信号传导在神经胶质瘤形成中的作用。
6. Expression of c-sis and platelet-derived growth factor in in vitro-transformed glioma cells from rat brain tissue transplacentally treated with ethylnitrosourea. [O] . P F Lens, B Altena, R Nusse 1986

机译：c-sis和血小板衍生的生长因子在乙基亚硝基脲经胎盘处理的大鼠脑组织体外转化的神经胶质瘤细胞中的表达。
7. Expression of c-sis and platelet-derived growth factor in in vitro-transformed glioma cells from rat brain tissue transplacentally treated with ethylnitrosourea. [O] . Lens, P F, Altena, B, Nusse, R 1986

机译：c-sis和血小板衍生的生长因子在乙基亚硝基脲经胎盘处理的大鼠脑组织体外转化的神经胶质瘤细胞中的表达。

Expression of c-sis and platelet-derived growth factor in in vitro-transformed glioma cells from rat brain tissue transplacentally treated with ethylnitrosourea.

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