Three breakpoints of variant t(2;8) translocations in Burkitt's lymphoma cells fall within a region 140 kilobases distal from c-myc.

B Henglein; H Synovzik; P Groitl; G W Bornkamm; P Hartl; M Lipp

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Three breakpoints of variant t(2;8) translocations in Burkitt's lymphoma cells fall within a region 140 kilobases distal from c-myc.

机译：Burkitt淋巴瘤细胞中的变体t（2; 8）易位的三个断点位于c-myc远端140 km的区域内。

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The variant translocations t(2;8) in Burkitt's lymphoma cells join band q24 of chromosome 8, distal from c-myc, to the Igkappa locus, with considerable variation in the location of the breakpoints on chromosome 8. We report the cloning and molecular characterization of a chromosome 8 region, distal from the c-myc locus, which encompasses the breakpoints of the Burkitt's lymphoma cell lines BL64, BL21, and LY91 within 11 kilobase pairs, termed provisionally bvr-1 (Burkitt's variants' rearranging region 1). Using probes from the c-myc, the bvr-1, and the human pvt-1 loci obtained by chromosome walking coupled with pulsed-field gel electrophoresis, we have constructed a physical map of the region 3' of c-myc. We map bvr-1 and pvt-1 about 140 and 260 kilobase pairs, respectively, distal from c-myc.

机译：Burkitt淋巴瘤细胞中的变体易位t（2; 8）连接了8号染色体的q24带（远离c-myc）到Igkappa基因座，在8号染色体上的断点位置有很大变化。我们报道了克隆和分子克隆c-myc基因座远端的8号染色体区域的特征，该区域涵盖11千碱基对内Burkitt淋巴瘤细胞系BL64，BL21和LY91的断裂点，临时称为bvr-1（Burkitt变异体的重排区域1）。使用通过染色体行走结合脉冲场凝胶电泳从c-myc，bvr-1和人pvt-1基因座获得的探针，我们构建了c-myc区域3'的物理图。我们将bvr-1和pvt-1分别映射到距c-myc约140和260千碱基对。

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《Molecular and Cellular Biology》 |1989年第5期|共9页
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B Henglein; H Synovzik; P Groitl; G W Bornkamm; P Hartl; M Lipp;
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中图分类细胞生物学;
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1. Identification of two distinct MYC breakpoint clusters and their association with various IGH breakpoint regions in the t(8;14) translocations in sporadic Burkitt-lymphoma [J] . K Busch, T Keller, U Fuchs, Leukemia . 2007,第8期

机译：散发性Burkitt淋巴瘤中t（8; 14）易位的两个不同MYC断点簇的识别及其与各种IGH断点区域的关联
2. Burkitt lymphoma cell line carrying a variant translocation creates new DNA at the breakpoint and violates the hierarchy of immunoglobulin gene rearrangement. [J] . C T Denny, G F Hollis, I T Magrath, Molecular and Cellular Biology . 1985,第11期

机译：携带变异易位的伯基特淋巴瘤细胞系在断点处产生新的DNA，并违反了免疫球蛋白基因重排的层次结构。
3. Burkitt lymphoma cell line carrying a variant translocation creates new DNA at the breakpoint and violates the hierarchy of immunoglobulin gene rearrangement. [J] . C T Denny, G F Hollis, I T Magrath, Molecular and Cellular Biology . 1985,第11期

机译：携带变异易位的伯基特淋巴瘤细胞系在断点处产生新的DNA，并违反了免疫球蛋白基因重排的层次结构。
4. Measuring the molecular force of Burkitt's lymphoma patient cells using AFM [C] . Li Mi, Liu Lianqing, Xi Ning, Proceedings of the IEEE 4th International Conference on Nano/Molecular Medicine and Engineering . 2010

机译：使用AFM测量Burkitt淋巴瘤患者细胞的分子力
5. Reactivation of Epstein-Barr Virus in Burkitt Lymphoma Cells in Response to Histone Deacetylase Inhibitors [D] . Daigle, Derek Alan 2011

机译：响应组蛋白脱乙酰基酶抑制剂的伯基特淋巴瘤细胞中爱泼斯坦-巴尔病毒的重新激活。
6. Three breakpoints of variant t(2;8) translocations in Burkitts lymphoma cells fall within a region 140 kilobases distal from c-myc. [O] . B Henglein, H Synovzik, P Groitl, 1989

机译：Burkitt淋巴瘤细胞中的变体t（2; 8）易位的三个断点位于c-myc远端140 kb的区域内。
7. Three breakpoints of variant t(2;8) translocations in Burkitt's lymphoma cells fall within a region 140 kilobases distal from c-myc. [O] . Henglein, B, Synovzik, H, Groitl, P, 1989

机译：Burkitt淋巴瘤细胞中的变体t（2; 8）易位的三个断点位于c-myc远端140 kb的区域内。

Three breakpoints of variant t(2;8) translocations in Burkitt's lymphoma cells fall within a region 140 kilobases distal from c-myc.

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