Induction of growth arrest by a temperature-sensitive p53 mutant is correlated with increased nuclear localization and decreased stability of the protein.

D Ginsberg; D Michael-Michalovitz; D Ginsberg; M Oren

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Induction of growth arrest by a temperature-sensitive p53 mutant is correlated with increased nuclear localization and decreased stability of the protein.

机译：温度敏感的p53突变体诱导的生长停滞与核定位增加和蛋白质稳定性降低有关。

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A temperature-sensitive mutant of p53, p53Val-135, was found to be able to arrest cell proliferation when overexpressed at 32.5 degrees C. While much of the protein was cytoplasmic in cells proliferating at 37.5 degrees C, it became predominantly nuclear at 32.5 degrees C. Concomitantly, p53Val-135 became destabilized, although not to the extent seen in primary fibroblasts.

机译：发现p53Val-135是对温度敏感的突变体，在32.5摄氏度下过表达时能够阻止细胞增殖。尽管大多数蛋白质在37.5摄氏度下增殖的细胞中呈细胞质，但在32.5摄氏度下主要变成核C.伴随地，p53Val-135变得不稳定，尽管没有达到在原代成纤维细胞中所见的程度。

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《Molecular and Cellular Biology》 |1991年第1期|共4页
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D Ginsberg; D Michael-Michalovitz; D Ginsberg; M Oren;
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中图分类细胞生物学;
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1. Molecular characterization of oncostatin M-induced growth arrest of MCF-7 cells expressing a temperature-sensitive mutant of p53. [J] . Li C, Shridhar K, Liu J Breast cancer research and treatment. . 2003,第1期

机译：抑癌素M诱导表达p53温度敏感突变体的MCF-7细胞生长停滞的分子表征。
2. Molecular Characterization of Oncostatin M-induced Growth Arrest of MCF-7 Cells Expressing a Temperature-Sensitive Mutant of p53 [J] . Cong Li, Kunju Shridhar, Jingwen Liu Breast Cancer Research and Treatment . 2003,第1期

机译：表达p53温度敏感突变体的瘤抑制素M诱导的MCF-7细胞生长停滞的分子表征
3. Induction of DNA Synthesis by Fibroblast Growth Factor in Temperature-Sensitive Cell-Cycle Mutants of Rat 3Y1 Fibroblasts Arrested at Restrictive Temperature [J] . Atsuyuki Okuda, Genki Kimura, Hideo Shimura, Cell structure and function . 1992,第1期

机译：成纤维细胞生长因子诱导温度限制的大鼠3Y1成纤维细胞温度敏感细胞周期突变体DNA合成的诱导
4. Selective tyrosine kinase inhibitor, STI571, inhibitsgrowth of p53 mutant anaplastic thyroid cancer cellsby inducing S-G2 transition arrest [C] . Alexei P. Podtcheko, Satoshi Tsuda, Akira Ohtsuru International Consortium for Medical Care of Hibakusha and Radiation Life Science . 2003

机译：选择性酪氨酸激酶抑制剂，STI571，P53突变体的抑制性诱导S-G2过渡逮捕的抑制性甲状腺癌细胞
5. RS-41, A multi-targeted kinase inhibitor, induces cell cycle arrest and apoptosis in P53 mutant and wild type models of upper gastrointestinal cancers. [D] . Visal, Tanvi. 2017

机译：RS-41是一种多靶点激酶抑制剂，在上消化道癌的P53突变型和野生型模型中诱导细胞周期停滞和凋亡。
6. Induction of growth arrest by a temperature-sensitive p53 mutant is correlated with increased nuclear localization and decreased stability of the protein. [O] . D Ginsberg, D Michael-Michalovitz, D Ginsberg, 1991

机译：温度敏感的p53突变体诱导的生长停滞与核定位增加和蛋白质稳定性降低有关。
7. Induction of growth arrest by a temperature-sensitive p53 mutant is correlated with increased nuclear localization and decreased stability of the protein. [O] . Ginsberg, D, Michael-Michalovitz, D, Oren, M 1991

机译：温度敏感的p53突变体诱导的生长停滞与核定位增加和蛋白质稳定性降低有关。

Induction of growth arrest by a temperature-sensitive p53 mutant is correlated with increased nuclear localization and decreased stability of the protein.

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