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首页> 外文期刊>Molecular and Cellular Biology >The yeast alpha 1 and MCM1 proteins bind a single strand of their duplex DNA recognition site.
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The yeast alpha 1 and MCM1 proteins bind a single strand of their duplex DNA recognition site.

机译：酵母alpha 1和MCM1蛋白结合其双链DNA识别位点的单链。

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The yeast cell type regulator alpha 1 cooperates with a constitutive factor, MCM1 protein, to recognize the promoter and activate transcription of several alpha-specific genes. I show here that the alpha 1 and MCM1 proteins bind specifically to one of the two strands of their recognition sequence. This single-strand-binding activity shares several characteristics with the duplex-binding properties of these proteins: (i) the MCM1 protein binds alone to single-stranded and duplex sequences of both the alpha-specific (P'Q) and a-specific (P) binding sites; (ii) the alpha 1 protein requires both the MCM1 protein and the Q sequence to bind either single-stranded or duplex DNA; (iii) the alpha 1 protein stimulates binding of the MCM1 protein to both single-stranded and duplex DNAs; and (iv) the affinities of the proteins for single-stranded and duplex DNAs are comparable.
机译：酵母细胞类型调节剂alpha 1与组成性因子MCM1蛋白协同作用，以识别启动子并激活几个alpha特异性基因的转录。我在这里表明，alpha 1和MCM1蛋白与它们的识别序列的两条链之一特异性结合。这种单链结合活性具有这些蛋白质的双链结合特性的几个特征：（i）MCM1蛋白单独结合到α-特异性（P'Q）和α-特异性的单链和双链序列（P）结合位点; （ii）alpha 1蛋白需要MCM1蛋白和Q序列都可以结合单链或双链DNA; （iii）alpha 1蛋白刺激MCM1蛋白与单链和双链DNA结合; （iv）蛋白质对单链和双链DNA的亲和力是可比的。

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