A viral long terminal repeat expressed in CD4+CD8+ precursors is downregulated in mature peripheral CD4-CD8+ or CD4+CD8- T cells.

Y Paquette; L Doyon; A Laperrière; Z Hanna; J Ball; R P Sekaly; P Jolicoeur

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A viral long terminal repeat expressed in CD4+CD8+ precursors is downregulated in mature peripheral CD4-CD8+ or CD4+CD8- T cells.

机译：CD4 + CD8 +前体中表达的病毒长末端重复序列在成熟的外周CD4-CD8 +或CD4 + CD8-T细胞中被下调。

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The long terminal repeat from a thymotropic mouse mammary tumor virus variant, DMBA-LV, was used to drive the expression of two reporter genes, murine c-myc and human CD4, in transgenic mice. Expression was observed specifically in thymic immature cells. Expression of c-myc in these cells induced oligoclonal CD4+ CD8+ T-cell thymomas. Expression of human CD4 was restricted to thymic progenitor CD4- CD8- and CD4+ CD8+ T cells and was shut off in mature CD4+ CD8- and CD4- CD8+ T cells, known to be derived from the progenitor double-positive T cells. These results suggest the existence of similar and common factors in CD4+ CD8- and CD4- CD8+ T cells and support a model of differentiation of CD4+ CD8+ T cells through common signal(s) involved in turning off the expression of the CD4 or CD8 gene.

机译：来自变态小鼠乳腺肿瘤病毒变体DMBA-LV的长末端重复序列被用于驱动转基因小鼠中鼠c-myc和人CD4这两个报告基因的表达。在胸腺未成熟细胞中特异性观察到表达。这些细胞中c-myc的表达诱导了寡克隆CD4 + CD8 + T细胞胸腺瘤。人CD4的表达仅限于胸腺祖细胞CD4- CD8-和CD4 + CD8 + T细胞，而在成熟的CD4 + CD8-和CD4- CD8 + T细胞中则被关闭，已知该细胞衍生自祖细胞双阳性T细胞。这些结果表明在CD4 + CD8-和CD4- CD8 + T细胞中存在相似和共同的因子，并支持通过关闭CD4或CD8基因表达的共同信号分化CD4 + CD8 + T细胞的模型。

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《Molecular and Cellular Biology》 |1992年第8期|共9页
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Y Paquette; L Doyon; A Laperrière; Z Hanna; J Ball; R P Sekaly; P Jolicoeur;
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中图分类细胞生物学;
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6. A viral long terminal repeat expressed in CD4+CD8+ precursors is downregulated in mature peripheral CD4-CD8+ or CD4+CD8- T cells. [O] . Y Paquette, L Doyon, A Laperrière, 1992

机译：CD4 + CD8 +前体中表达的病毒长末端重复序列在成熟的外周CD4-CD8 +或CD4 + CD8-T细胞中被下调。
7. A viral long terminal repeat expressed in CD4+CD8+ precursors is downregulated in mature peripheral CD4-CD8+ or CD4+CD8- T cells. [O] . Paquette, Y, Doyon, L, Laperrière, A, 1992

机译：CD4 + CD8 +前体中表达的病毒长末端重复序列在成熟的外周CD4-CD8 +或CD4 + CD8-T细胞中被下调。

A viral long terminal repeat expressed in CD4+CD8+ precursors is downregulated in mature peripheral CD4-CD8+ or CD4+CD8- T cells.

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