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首页> 外文期刊>Molecular and Cellular Biology >The human immunodeficiency virus type 1 Rev protein shuttles between the cytoplasm and nuclear compartments.
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The human immunodeficiency virus type 1 Rev protein shuttles between the cytoplasm and nuclear compartments.

机译：人类免疫缺陷病毒1型Rev蛋白在细胞质和核区室之间穿梭。

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摘要

A retroviral regulatory protein, Rev (regulator of virion protein expression), is made in cells infected by human immunodeficiency virus (HIV). Rev is essential for the completion of the retroviral life cycle and interacts with the host cell at some posttranscriptional step in order to express the incompletely spliced HIV mRNAs from which HIV structural proteins are translated. Neither the host cell components nor the mechanisms responsible for this important regulation have been defined. We now report that Rev is a nucleocytoplasmic shuttle protein which is continuously transported between the cytoplasm, the nucleoli, and nucleoplasmic speckles enriched in RNA splicing and processing factors. The results show that Rev has the potential to interfere specifically with the splicing of the HIV pre-mRNA in the nucleoplasm and, next, guide such mRNAs to the cytoplasm for translation.
机译：逆转录病毒调节蛋白Rev（病毒体蛋白表达的调节剂）是在被人类免疫缺陷病毒（HIV）感染的细胞中制成的。 Rev对于完成逆转录病毒生命周期至关重要，并在转录后的某些步骤与宿主细胞相互作用，以表达不完整剪接的HIV mRNA，从中翻译出HIV结构蛋白。尚未定义宿主细胞组分或负责该重要调控的机制。我们现在报告Rev是一种核质穿梭蛋白，它在富含RNA剪接和加工因子的胞质，核仁和核质斑点之间连续运输。结果表明，Rev可能具有特异性干扰HIV pre-mRNA在核质中的剪接的能力，然后将此类mRNA导向细胞质进行翻译。

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