Morphological transformation of established rodent cell lines by high-level expression of the adenovirus type 2 E1a gene.

A W Senear; J B Lewis

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Morphological transformation of established rodent cell lines by high-level expression of the adenovirus type 2 E1a gene.

机译：通过2型腺病毒E1a基因的高水平表达建立的啮齿动物细胞系的形态转化。

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When a strong promoter derived from the mouse metallothionein gene was substituted for the homologous adenovirus type 2 E1a promoter, leading to enhanced levels of E1a RNAs and proteins in cells transfected with the chimeric gene, the E1a gene alone was able to induce in established cell lines alterations in cellular morphology and growth properties similar to those produced by the combined action of E1a and E1b genes. The qualitative effects of E1a gene expression upon cellular properties thus depend on the level of expression of the E1a gene. Furthermore, E1a may be the primary transforming gene of adenoviruses, since it produced many of the characteristics of transformed cells that had previously been attributed to E1b.

机译：当将源自小鼠金属硫蛋白基因的强启动子替换为同源2型腺病毒E1a启动子，导致嵌合基因转染的细胞中E1a RNA和蛋白质水平提高时，仅E1a基因就能在已建立的细胞系中诱导细胞形态和生长特性的改变类似于E1a和E1b基因的联合作用产生的改变。 E1a基因表达对细胞特性的定性影响因此取决于E1a基因的表达水平。此外，E1a可能是腺病毒的主要转化基因，因为它产生了以前归因于E1b的许多转化细胞特征。

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《Molecular and Cellular Biology》 |1986年第4期|共8页
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A W Senear; J B Lewis;
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中图分类细胞生物学;
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机译：腺病毒5 E1A负责增加已建立的腺病毒5转化细胞系中胰岛素受体底物4的表达，并与IRS组分相互作用，激活PI3激酶| [sol] | Akt信号通路
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机译：腺病毒5 E1A负责增加已建立的腺病毒5转化细胞系中胰岛素受体底物4的表达，并与IRS组分相互作用，激活PI3激酶| [sol] | Akt信号通路
3. Two domains within the adenovirus type 12 E1A unique spacer have disparate effects on the interaction of E1A with P105-Rb and the transformation of primary mouse cells. [J] . Rumpf H, Esche H, Kirch HC Virology . 1999,第1期

机译：腺病毒12型E1A独特间隔区中的两个结构域对E1A与P105-Rb的相互作用以及原代小鼠细胞的转化具有不同的影响。
4. Enhanced Gene Expression in Coxsackie-Adenovirus Receptor Deficient Cells by Anionic LiposomeEncapsulated Adenovirus [C] . Zhirong Zhong, Zhirong Zhang, Xun Sun Annual meeting exposition of the Controlled Release Society . 2009

机译：阴离子脂质体包封的腺病毒增强柯萨奇-腺病毒受体缺陷细胞中的基因表达
5. Adenovirus E1A 12S-induced changes during immortalization and transformation of primary epithelial cells. [D] . Gopalakrishnan, Shobha. 1996

机译：腺病毒E1A 12S诱导的原代上皮细胞永生化和转化过程中的变化。
6. Morphological transformation of established rodent cell lines by high-level expression of the adenovirus type 2 E1a gene. [O] . A W Senear, J B Lewis 1986

机译：通过2型腺病毒E1a基因的高水平表达建立的啮齿动物细胞系的形态转化。
7. Morphological transformation of established rodent cell lines by high-level expression of the adenovirus type 2 E1a gene. [O] . Senear, A W, Lewis, J B 1986

机译：通过2型腺病毒E1a基因的高水平表达建立的啮齿动物细胞系的形态转化。

Morphological transformation of established rodent cell lines by high-level expression of the adenovirus type 2 E1a gene.

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