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首页> 外文期刊>Molecular and Cellular Biology >Repair of specific base pair mismatches formed during meiotic recombination in the yeast Saccharomyces cerevisiae.
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Repair of specific base pair mismatches formed during meiotic recombination in the yeast Saccharomyces cerevisiae.

机译：修复酿酒酵母减数分裂重组过程中形成的特定碱基对错配。

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摘要

Heteroduplexes formed between DNA strands derived from different homologous chromosomes are an intermediate in meiotic crossing over in the yeast Saccharomyces cerevisiae and other eucaryotes. A heteroduplex formed between wild-type and mutant genes will contain a base pair mismatch; failure to repair this mismatch will lead to postmeiotic segregation (PMS). By analyzing the frequency of PMS for various mutant alleles in the yeast HIS4 gene, we showed that C/C mismatches were inefficiently repaired relative to all other point mismatches. These other mismatches (G/G, G/A, T/T, A/A, T/C, C/A, A/A, and T/G) were repaired with approximately the same efficiency. We found that in spores with unrepaired mismatches in heteroduplexes, the nontranscribed strand of the HIS4 gene was more frequently donated than the transcribed strand. In addition, the direction of repair for certain mismatches was nonrandom.
机译：在源自不同同源染色体的DNA链之间形成的异源双链体是酿酒酵母和其他真核生物减数分裂交换的中间产物。在野生型和突变基因之间形成的异源双链体将包含碱基对错配。无法修复这种失配将导致减数分裂后隔离（PMS）。通过分析酵母HIS4基因中各种突变等位基因的PMS频率，我们发现相对于所有其他点错配，C / C错配修复效率低下。这些其他不匹配（G / G，G / A，T / T，A / A，T / C，C / A，A / A和T / G）的修复效率几乎相同。我们发现，在异源双链体中具有未修复的错配的孢子中，HIS4基因的非转录链比转录链更常被捐赠。此外，某些不匹配的修复方向也不是随机的。

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