Mutations in the Drosophila gene encoding ribosomal protein S6 cause tissue overgrowth.

M J Stewart; R Denell

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Mutations in the Drosophila gene encoding ribosomal protein S6 cause tissue overgrowth.

机译：果蝇基因编码核糖体蛋白S6的突变导致组织过度生长。

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We have characterized two P-element-induced, lethal mutations in Drosophila melanogaster which affect the larval hemocytes, mediators of the insect immune response. Each mutant displays larval melanotic tumors characteristic of mutations affecting the insect cellular immune system, and the moribund animals develop grossly hypertrophied hematopoietic organs because of increased cell proliferation and extra rounds of endoreduplication in some hematopoietic cells. Surprisingly, these mutations are due to P element insertions in the 5' regulatory region of the Drosophila gene encoding ribosomal protein S6 and cause a reduction of S6 transcript abundance in mutant larvae.

机译：我们已经表征了果蝇黑腹果蝇中两个P元素诱导的致死突变，这些突变影响幼虫血细胞，昆虫免疫反应的介体。每个突变体均表现出幼虫性黑色素瘤肿瘤，其特征在于影响昆虫细胞免疫系统的突变，并且垂死的动物由于某些细胞中增殖的增加和核内复制的增加而发展出肥大的造血器官。令人惊讶地，这些突变是由于在果蝇编码核糖体蛋白S6的基因的5'调节区中的P元件插入而引起的，在突变体幼虫中S6转录物丰度的降低。

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《Molecular and Cellular Biology》 |1993年第4期|共12页
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M J Stewart; R Denell;
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中图分类细胞生物学;
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1. A gene encoding a mitogen-activated protein kinase kinase kinase is induced simultaneously with genes for a mitogen-activated protein kinase and an S6 ribosomal protein kinase by touch, cold, and water stress in Arabidopsis thaliana [J] . Tsuyoshi Mizoguchi, Kenji Irie, Takashi Hirayama Proceedings of the National Academy of Sciences of the United States of America . 1996,第2期

机译：在拟南芥中，通过接触，寒冷和水分胁迫，同时诱导编码有丝分裂原活化蛋白激酶激酶的基因与有丝分裂原活化蛋白激酶和S6核糖体蛋白激酶的基因。
2. The two Arabidopsis RPS6 genes, encoding for cytoplasmic ribosomal proteins S6, are functionally equivalent [J] . Audrey Creff, Rodnay Sormani, Thierry Desnos Plant Molecular Biology . 2010,第s4a5期

机译：编码胞质核糖体蛋白S6的两个拟南芥RPS6基因在功能上等效
3. The two Arabidopsis RPS6 genes, encoding for cytoplasmic ribosomal proteins S6, are functionally equivalent [J] . Creff A., Sormani R., Desnos T. Plant Molecular Biology . 2010,第4a5期

机译：编码胞质核糖体蛋白S6的两个拟南芥RPS6基因在功能上等效
4. CLONING AND EXPRESSION OF RIBOSOMAL PROTEIN S6 GENE IN INNER MONGOLIA CASHMERE GOAT [C] . Wang Zhigang, Hao Xiyan, Ma Jiannan, The 6'th International Forum on Post-genome Technologies(6'IFPT)（第六届国际后基因组生命科学技术学术论坛） . 2009

机译：核糖体蛋白S6基因在内蒙古棉山羊中的克隆与表达
5. Structural and functional analysis of bone morphogenetic proteins: Crystal structure of bone morphogenetic protein-9, binding studies with pro-domain and receptors, and mutational studies in Drosophila decapentaplegic [D] . Brown, Monica Anne 2008

机译：骨形态发生蛋白9的结构和功能分析：骨形态发生蛋白9的晶体结构，与前域和受体的结合研究以及果蝇十足性果蝇的突变研究
6. Mutations in the Drosophila gene encoding ribosomal protein S6 cause tissue overgrowth. [O] . M J Stewart, R Denell 1993

机译：果蝇编码核糖体蛋白S6的基因突变导致组织过度生长。
7. Mutations in the Drosophila gene encoding ribosomal protein S6 cause tissue overgrowth. [O] . Stewart, M J, Denell, R 1993

机译：果蝇编码核糖体蛋白S6的基因突变导致组织过度生长。

Mutations in the Drosophila gene encoding ribosomal protein S6 cause tissue overgrowth.

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