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首页> 外文期刊>Molecular and Cellular Biology >AFR1 acts in conjunction with the alpha-factor receptor to promote morphogenesis and adaptation.
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AFR1 acts in conjunction with the alpha-factor receptor to promote morphogenesis and adaptation.

机译：AFR1与α因子受体协同作用，促进形态发生和适应。

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摘要

Mating pheromone receptors activate a G-protein signaling pathway that induces changes in transcription, cell division, and morphogenesis needed for the conjunction of Saccharomyces cerevisiae. The C terminus of the alpha-factor pheromone receptor functions in two complex processes, adaptation and morphogenesis. Adaptation to alpha-factor may occur through receptor desensitization, and alpha-factor-induced morphogenesis forms the conjugation bridge between mating cells. A plasmid overexpression strategy was used to isolate a new gene, AFR1, which acts together with the receptor C terminus to promote adaptation. The expression of AFR1 was highly induced by alpha-factor. Unexpectedly, cells lacking AFR1 showed a defect in alpha-factor-stimulated morphogenesis that was similar to the morphogenesis defect observed in cells producing C-terminally truncated alpha-factor receptors. In contrast, AFR1 overexpression resulted in longer projections of morphogenesis, which suggests that this gene may directly stimulate morphogenesis. These results indicate that AFR1 encodes a developmentally regulated function that coordinates both the regulation of receptor signaling and the induction of morphogenesis during conjugation.
机译：交配信息素受体激活了G蛋白信号传导途径，该途径可诱导酿酒酵母结合所需的转录，细胞分裂和形态发生变化。 α因子信息素受体的C末端在两个复杂的过程中起作用，即适应和形态发生。对α-因子的适应可能通过受体脱敏而发生，并且α-因子诱导的形态发生形成了交配细胞之间的共轭桥。质粒过表达策略用于分离新基因AFR1，该基因与受体C端一起起作用以促进适应。 AFR1的表达被alpha因子高度诱​​导。出乎意料的是，缺乏AFR1的细胞在α因子刺激的形态发生中表现出缺陷，类似于在产生C端截短的α因子受体的细胞中观察到的形态发生缺陷。相反，AFR1的过表达导致更长的形态发生预测，这表明该基因可能直接刺激形态发生。这些结果表明，AFR1编码了一种发育受调节的功能，该功能可调节受体信号传导的调节和缀合过程中形态发生的诱导。

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