Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13.

T L Yi; J L Cleveland; J N Ihle

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Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13.

机译：含有SH2结构域的蛋白酪氨酸磷酸酶：特征，在造血细胞中的优先表达以及定位于人类染色体12p12-p13。

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Protein tyrosine phosphorylation has been implicated in the growth and functional responses of hematopoietic cells. Recently, approaches have been developed to characterize the protein tyrosine phosphatases that may contribute to regulation of protein tyrosine phosphorylation. One novel protein tyrosine phosphatase was expressed predominantly in hematopoietic cells. Hematopoietic cell phosphatase encodes a 68-kDa protein that contains a single phosphatase conserved domain. Unlike other known protein tyrosine phosphatases, hematopoietic cell phosphatase contains two src homology 2 domains. We also cloned the human homolog, which has 95% amino acid sequence identity. Both the murine and human gene products have tyrosine-specific phosphatase activity, and both are expressed predominantly in hematopoietic cells. Importantly, the human gene maps to chromosome 12 region p12-p13. This region is associated with rearrangements in approximately 10% of cases of acute lymphocytic leukemia in children.

机译：蛋白质酪氨酸磷酸化与造血细胞的生长和功能反应有关。近来，已经开发出表征蛋白质酪氨酸磷酸酶的方法，其可能有助于蛋白质酪氨酸磷酸化的调节。一种新的蛋白质酪氨酸磷酸酶主要在造血细胞中表达。造血细胞磷酸酶编码一个68 kDa的蛋白质，其中包含一个保守的磷酸酶结构域。与其他已知的蛋白质酪氨酸磷酸酶不同，造血细胞磷酸酶含有两个src同源2域。我们还克隆了具有95％氨基酸序列同一性的人同源物。鼠类和人类基因产物均具有酪氨酸特异性磷酸酶活性，并且两者均主要在造血细胞中表达。重要的是，人类基因定位于12号染色体p12-p13区。在大约10％的儿童急性淋巴细胞白血病病例中，该区域与重排有关。

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《Molecular and Cellular Biology》 |1992年第2期|共11页
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T L Yi; J L Cleveland; J N Ihle;
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中图分类细胞生物学;
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1. Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences. [J] . R J Matthews, D B Bowne, E Flores, Molecular and Cellular Biology . 1992,第5期

机译：造血细胞内蛋白酪氨酸磷酸酶的表征：一种磷酸酶的描述，该磷酸酶包含一个SH2域和另一个富含脯氨酸，谷氨酸，丝氨酸和苏氨酸的序列。
2. Chromosomal localization of the protein tyrosine phosphatase G1 gene and characterization of the aberrant transcripts in human colon cancer cells [J] . Adachi Masaaki, Ariyama Takeshi, Hinoda Yuji, FEBS Letters . 1994,第3期

机译：酪氨酸磷酸酶G1基因的染色体定位及人结肠癌细胞中异常转录本的表征
3. Expression and Characterization of Catalytic Domain of T Cell Protein Tyrosine Phosphatase(ΔTC-PTP) ―Immunohistochemical Study of ΔTC-PTP Expression in Non-small Cell Lung Carcinomas [J] . ZHU Zhi-cheng, SUN Mei, ZHANG Xing-yi, Chemical Research in Chinese Universities . 2007,第3期

机译：T细胞蛋白酪氨酸磷酸酶（ΔTC-PTP）催化结构域的表达与表征-非小细胞肺癌ΔTC-PTP表达的免疫组织化学研究
4. Structure and peptide binding specificity of the SH3 and SH2 domain from a self-regulated protein tyrosine kinase-BTK [C] . Jya-Wei Cheng, Shiou-Ru Tzeng, Ming-Tao Pai the International Peptide Symposium . 2001

机译：来自自调节蛋白酪氨酸激酶-BTK的SH3和SH2结构域的结构和肽结合特异性
5. Identification of SH2 -domain containing protein tyrosine phosphatase SHP-2 targets in physiological and pathophysiological cell signaling [D] . Eminaga, Seda 2007

机译：生理和病理生理细胞信号转导中含有SH2结构域的蛋白酪氨酸磷酸酶SHP-2靶标的鉴定
6. Protein tyrosine phosphatase containing SH2 domains: characterization preferential expression in hematopoietic cells and localization to human chromosome 12p12-p13. [O] . T L Yi, J L Cleveland, J N Ihle 1992

机译：含有SH2结构域的蛋白酪氨酸磷酸酶：特征在造血细胞中优先表达以及定位于人类12p12-p13染色体。
7. Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13. [O] . Yi, T L, Cleveland, J L, Ihle, J N 1992

机译：含有SH2结构域的蛋白酪氨酸磷酸酶：特征，在造血细胞中优先表达以及定位于人类12p12-p13染色体。

Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13.

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