Elements and factors involved in tissue-specific and embryonic expression of the liver transcription factor LFB1 in Xenopus laevis.

D Zapp; S Bartkowski; B Holewa; C Zoidl; L Klein-Hitpass; G U Ryffel

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Elements and factors involved in tissue-specific and embryonic expression of the liver transcription factor LFB1 in Xenopus laevis.

机译：爪蟾肝脏转录因子LFB1的组织特异性和胚胎表达中涉及的元素和因素。

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LFB1 (HNF1) is a tissue-specific transcription factor found in the livers, stomachs, intestines, and kidneys of vertebrates. By analyzing the promoter of the Xenopus LFB1 gene, we identified potential autoregulation by LFB1 and regulation by HNF4, a transcription factor with a tissue distribution similar to that of LFB1. Injection of LFB1 promoter-chloramphenicol acetyltransferase constructs into Xenopus eggs revealed embryonic activation that is restricted to the region of the developing larvae expressing endogeneous LFB1. Proper embryonic activation was also observed with a rat LFB1 promoter. Deletion analysis of the Xenopus and rat promoters revealed that in both promoters embryonic activation is absolutely dependnet on the presence of an element that contains CCNCTCTC as the core consensus sequence. Since this element is recognized by the maternal factor OZ-1 previously described by N. Ovsenek, A. M. Zorn, and P. A. Krieg (Development 115:649-655, 1992), we might have identified the main constituents of a hierarchy that leads via LFB1 to the activation of tissue-specific genes during embryogenesis.

机译：LFB1（HNF1）是一种在脊椎动物的肝，胃，肠和肾中发现的组织特异性转录因子。通过分析非洲爪蟾LFB1基因的启动子，我们确定了潜在的LFB1自动调节和HNF4的调节，HNF4是一种与LFB1相似的组织分布的转录因子。在非洲爪蟾卵中注射LFB1启动子-氯霉素乙酰基转移酶构建体表明，胚胎的激活仅限于表达内源性LFB1的发育中幼虫的区域。还使用大鼠LFB1启动子观察到正确的胚胎激活。对非洲爪蟾和大鼠启动子的缺失分析表明，在这两个启动子中，胚胎激活绝对依赖于包含CCNCTCTC作为核心共有序列的元素的存在。由于该元素已被N.Ovsenek，AM Zorn和PA Krieg（开发115：649-655，1992年）先前所述的母源因子OZ-1识别，因此我们可能已经确定了通过LFB1引导的层次结构的主要组成在胚胎发生过程中激活组织特异性基因。

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《Molecular and Cellular Biology》 |1993年第10期|共11页
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D Zapp; S Bartkowski; B Holewa; C Zoidl; L Klein-Hitpass; G U Ryffel;
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中图分类细胞生物学;
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1. Developmental regulation and tissue distribution of the liver transcription factor LFB1 (HNF1) in Xenopus laevis. [J] . S Bartkowski, D Zapp, H Weber, Molecular and Cellular Biology . 1993,第1期

机译：非洲爪蟾肝脏转录因子LFB1（HNF1）的发育调节和组织分布。
2. The embryonic expression of the tissue-specific transcription factor HNF1alpha in Xenopus: rapid activation by HNF4 and delayed induction by mesoderm inducers. [J] . Nastos A, Pogge-von-Strandmann E, Weber H, Nucleic Acids Research . 1998,第24期

机译：组织特异性转录因子HNF1alpha在非洲爪蟾中的胚胎表达：HNF4的快速激活和中胚层诱导剂的延迟诱导。
3. The embryonic expression of the tissue-specific transcription factor HNF1α in Xenopus: Rapid activation by HNF4 and delayed induction by mesoderm inducers [J] . Aristotelis Nastos, Elke Pogge von Strandmann, Gerhart U. Ryffel, Nucleic acids research . 1998,第24期

机译：组织特异性转录因子HNF1α在非洲爪蟾中的胚胎表达：HNF4的快速激活和中胚层诱导剂的延迟诱导
4. Discovering Typical Transcription-Factors Patterns in Gene Expression Levels of Mouse Embryonic Stem Cells by Instance-Based Classifiers [C] . Francesco Gagliardi, Claudia Angelini International conference on image analysis and processing . 2013

机译：通过基于实例的分类器发现小鼠胚胎干细胞基因表达水平的典型转录因子模式。
5. Exploration of the cis-elements and trans-factors involved in post-transcriptional mechanisms of the gene atpI in chloroplast gene expression [D] . Smithers, Emily Rose 2011

机译：探索叶绿体基因表达中atpI基因转录后机制的顺式和反式因子
6. Elements and factors involved in tissue-specific and embryonic expression of the liver transcription factor LFB1 in Xenopus laevis. [O] . D Zapp, S Bartkowski, B Holewa, 1993

机译：爪蟾肝脏转录因子LFB1的组织特异性和胚胎表达中涉及的元素和因素。
7. Elements and factors involved in tissue-specific and embryonic expression of the liver transcription factor LFB1 in Xenopus laevis. [O] . Zapp, D, Bartkowski, S, Holewa, B, 1993

机译：爪蟾肝脏转录因子LFB1的组织特异性和胚胎表达中涉及的元素和因素。

Elements and factors involved in tissue-specific and embryonic expression of the liver transcription factor LFB1 in Xenopus laevis.

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