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首页> 外文期刊>Molecular and Cellular Biology >Two Drosophila melanogaster tropomyosin genes: structural and functional aspects.
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Two Drosophila melanogaster tropomyosin genes: structural and functional aspects.

机译：两个果蝇果蝇原肌球蛋白基因：结构和功能方面。

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We compared the structure and function of the two Drosophila melanogaster tropomyosin genes. The most striking structural aspect was their size disparity. Codons 1 through 257 of gene 2 occupied 833 nucleotides and contained only one intron, whereas the corresponding region of gene 1 occupied 17.5 kilobases and was interrupted by eight introns. The intron-exon arrangement of gene 1 reflected evolutionary expansion of tropomyosin via 42- and 49-residue duplications, which are probably actin-binding domains. Functionally, gene 1 was considerably more complex than gene 2; it was active in both muscle and nonmuscle cell lineages, had at least five variable exons, and specified a minimum of five developmentally regulated isoforms. Two of these isoforms, which accumulated only in flight muscles, were unprecedented fusion proteins in which the tropomyosin sequence was joined to a carboxy-terminal proline-rich domain.
机译：我们比较了两个果蝇果蝇原肌球蛋白基因的结构和功能。结构上最引人注目的是它们的尺寸差异。基因2的1至257密码子占833个核苷酸，仅包含一个内含子，而基因1的相应区域占17.5 kb，被8个内含子打断。基因1的内含子-外显子排列反映了原肌球蛋白通过42和49个残基重复的进化扩展，这可能是肌动蛋白结合域。从功能上讲，基因1比基因2复杂得多。它在肌肉和非肌肉细胞谱系中均活跃，具有至少五个外显子，并指定了至少五个发育调控的亚型。这些同工型中的两个仅在飞行肌肉中蓄积，是前所未有的融合蛋白，其中原肌球蛋白序列连接到富含羧基末端脯氨酸的结构域。

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