Regulation of tissue factor gene expression in the monocyte procoagulant response to endotoxin.

S A Gregory; J H Morrissey; T S Edgington

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Regulation of tissue factor gene expression in the monocyte procoagulant response to endotoxin.

机译：单核细胞对内毒素的促凝反应中组织因子基因表达的调节。

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Tissue factor is the cellular receptor and cofactor for plasma factor VIIa which initiates the coagulation protease cascade on cell surfaces. Although normally absent from all intravascular cell types, tissue factor can be induced to appear on circulating monocytes and vascular endothelial cells by specific inflammatory or immunological mediators. In this study, we have examined the regulation of endotoxin-induced tissue factor gene expression in peripheral blood monocytes.

机译：组织因子是血浆因子VIIa的细胞受体和辅因子，可启动细胞表面的凝血蛋白酶级联反应。尽管通常在所有血管内细胞类型中都不存在，但是组织因子可以通过特异性的炎性或免疫学介质诱导出现在循环单核细胞和血管内皮细胞上。在这项研究中，我们检查了内毒素诱导的外周血单核细胞中组织因子基因表达的调节。

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《Molecular and Cellular Biology》 |1989年第6期|共4页
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S A Gregory; J H Morrissey; T S Edgington;
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中图分类细胞生物学;
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1. Monocyte IL-10 produced in response to lipopolysaccharide modulates thrombin generation by inhibiting tissue factor expression and release of active tissue factor-bound microparticles. [J] . Poitevin S, Cochery-Nouvellon E, Dupont A, Thrombosis and Haemostasis: Journal of the International Society on Thrombosis and Haemostasis . 2007,第4期

机译：响应脂多糖而产生的单核细胞IL-10通过抑制组织因子的表达和活性组织因子结合的微粒的释放来调节凝血酶的产生。
2. Highly Purified Lipoteichoic Acid from Staphylococcus aureus Induces Procoagulant Activity and Tissue Factor Expression in Human Monocytes but Is a Weak Inducer in Whole Blood: Comparison with Peptidoglycan [J] . Eva Mattsson, Thomas Hartung, Siegfried Morath, Infection and immunity . 2004,第7期

机译：来自金黄色葡萄球菌的高度纯化的脂磷壁酸诱导人单核细胞的促凝血活性和组织因子表达，但在全血中却是弱诱导剂：与肽聚糖的比较
3. Peptidoglycan from Staphylococcus aureus Induces Tissue Factor Expression and Procoagulant Activity in Human Monocytes [J] . Eva Mattsson, Heiko Herwald, Lars Bj?rck, Infection and immunity . 2002,第6期

机译：金黄色葡萄球菌的肽聚糖诱导人单核细胞中组织因子的表达和促凝活性
4. High Levels of Human Factor IX Transgene Expression in Mice Increase Blood Procoagulant Activity [C] . M. A. Srour, J. Grupp, Th. Albert, Hemophilia Symposium . 2008

机译：小鼠中高水平的人体因子IX转基因表达增加血液探剂活性
5. Positive and negative regulation of neuroendocrine gene expression by zinc finger transcription factors: Identification of a negative retinoic acid response element in the rat oxytocin promoter, and the cloning of a novel factor binding a conserved element critical for effective expression of the growth hormone gene [D] . Lipkin, Steven Monroe 1993

机译：锌指转录因子对神经内分泌基因表达的正向和负向调节：鉴定大鼠催产素启动子中的视黄酸阴性反应元件，并克隆与保守元件结合的新型因子，该元件对于生长激素基因的有效表达至关重要
6. Regulation of tissue factor gene expression in the monocyte procoagulant response to endotoxin. [O] . S A Gregory, J H Morrissey, T S Edgington 1989

机译：单核细胞对内毒素的促凝反应中组织因子基因表达的调节。
7. Regulation of tissue factor gene expression in the monocyte procoagulant response to endotoxin. [O] . Gregory, S A, Morrissey, J H, Edgington, T S 1989

机译：单核细胞对内毒素的促凝反应中组织因子基因表达的调节。

Regulation of tissue factor gene expression in the monocyte procoagulant response to endotoxin.

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