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首页> 外文期刊>Molecular and Cellular Biology >Retinoic acid blocks adipogenesis by inhibiting C/EBPbeta-mediated transcription.
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Retinoic acid blocks adipogenesis by inhibiting C/EBPbeta-mediated transcription.

机译：维甲酸通过抑制C / EBPbeta介导的转录来阻止脂肪形成。

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Adipocyte differentiation is thought to involve sequential induction of the transcription factors C/EBPbeta, peroxisome proliferator-activated receptor gamma (PPARgamma), and C/EBPalpha. C/EBPalpha expression is both necessary and sufficient for adipocyte differentiation. Here we report that ectopic expression of either C/EBPalpha or C/EBPbeta induces PPARgamma expression and adipogenesis and that retinoic acid (RA) completely inhibits adipogenesis by either form of C/EBP. In studies of normal preadipocytes, RA does not prevent C/EBPbeta induction but blocks induction of PPARgamma, C/EBPalpha, and adipogenesis. In transient transfection studies, liganded RA receptor (RAR) specifically blocks transcriptional activation by either C/EBPalpha or C/EBPbeta. These results strongly suggest that C/EBPalpha substitutes for C/EBPbeta to induce adipocyte differentiation and that liganded RAR inhibits adipogenesis by blocking C/EBPbeta-mediated induction of downstream genes.
机译：脂肪细胞的分化被认为涉及转录因子C / EBPbeta，过氧化物酶体增殖物激活的受体γ（PPARgamma）和C / EBPalpha的顺序诱导。 C / EBPalpha表达对于脂肪细胞分化既必要又足够。在这里，我们报告异位表达的C / EBPalpha或C / EBPbeta诱导PPARgamma表达和脂肪生成，并且视黄酸（RA）完全抑制脂肪生成的任何形式的C / EBP。在正常前脂肪细胞的研究中，RA不会阻止C / EBPbeta的诱导，但会阻止PPARgamma，C / EBPalpha和脂肪形成的诱导。在瞬时转染研究中，配体RA受体（RAR）特异性地阻断C / EBPalpha或C / EBPbeta的转录激活。这些结果强烈表明，C / EBPalpha替代了C / EBPbeta以诱导脂肪细胞分化，并且配体的RAR通过阻断C / EBPbeta介导的下游基因诱导而抑制了脂肪形成。

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