Chondromodulin I (ChM-I) was supposed from its limited expression in cartilage and its functions in cultured chondrocytes as a major regulator in cartilage development. Here, we generated mice deficient in ChM-I by targeted disruption of the ChM-I gene. No overt abnormality was detected in endochondral bone formation during embryogenesis and cartilage development during growth stages of ChM-I?/? mice. However, a significant increase in bone mineral density with lowered bone resorption with respect to formation was unexpectedly found in adult ChM-I?/? mice. Thus, the present study established that ChM-I is a bone remodeling factor.
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机译：软骨调节蛋白I（ChM-1）可能是由于其在软骨中的有限表达以及在培养的软骨细胞中作为软骨发育的主要调节剂而发挥的作用。在这里，我们通过 ChM-1 基因的定向破坏产生了ChM-1缺陷的小鼠。在ChM-I l /？小鼠的生长期，在胚胎发生和软骨发育过程中未发现明显的软骨内骨形成异常。然而，出乎意料的是，在成年ChM-1 l /？小鼠中发现骨矿物质密度显着增加，而骨吸收相对于形成降低。因此，本研究确定ChM-1是骨重塑因子。
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