The Tumor Suppressor p53 Inhibits Net, an Effector of Ras/Extracellular Signal-Regulated Kinase Signaling

Koji Nakade; Hong Zheng; Gitali Ganguli; Gilles Buchwalter; Christian Gross; Bohdan Wasylyk

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The Tumor Suppressor p53 Inhibits Net, an Effector of Ras/Extracellular Signal-Regulated Kinase Signaling

机译：肿瘤抑制因子p53抑制网，Ras /细胞外信号调节激酶信号转导的效应器。

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The tumor suppressor function of p53 is linked to its ability to repress gene expression, but the mechanisms of specific gene repression are poorly understood. We report that wild-type p53 inhibits an effector of the Ras oncogene/mitogen-activated protein (MAP) kinase pathway, the transcription factor Net. Tumor-associated mutant p53s are less efficient inhibitors. p53 inhibits by preventing phosphorylation of Net by MAP kinases. Loss of p53 in vivo leads to increased Net phosphorylation in response to wound healing and UV irradiation of skin. Our results show that p53 can repress specific gene expression by inhibiting Net, a factor implicated in cell cycle entry.

机译：p53的肿瘤抑制功能与其抑制基因表达的能力有关，但对特定基因抑制的机制了解甚少。我们报告说，野生型p53抑制Ras癌基因/有丝分裂原激活的蛋白（MAP）激酶途径，转录因子Net的效应器。肿瘤相关的突变体p53s是效率较低的抑制剂。 p53通过阻止MAP激酶使Net磷酸化而抑制。体内p53的丢失导致响应伤口愈合和皮肤紫外线照射而增加的净磷酸化。我们的结果表明，p53可以通过抑制Net（一种参与细胞周期进入的因子）来抑制特定基因的表达。

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《Molecular and Cellular Biology》 |2004年第3期|共11页
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Koji Nakade; Hong Zheng; Gitali Ganguli; Gilles Buchwalter; Christian Gross; Bohdan Wasylyk;
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中图分类细胞生物学;
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6. The Tumor Suppressor p53 Inhibits Net an Effector of Ras/Extracellular Signal-Regulated Kinase Signaling [O] . Koji Nakade, Hong Zheng, Gitali Ganguli, 2004

机译：肿瘤抑制因子p53抑制网是Ras /细胞外信号调节激酶信号转导的效应子。
7. The Tumor Suppressor p53 Inhibits Net, an Effector of Ras/Extracellular Signal-Regulated Kinase Signaling [O] . Nakade, Koji, Zheng, Hong, Ganguli, Gitali, 2004

机译：肿瘤抑制因子p53抑制网，是Ras /细胞外信号调节激酶信号转导的效应子。
8. Hepatocyte Growth Factor Inhibits Apoptosis by the Profibrotic Factor Angiotensin II via Extracellular Signal-regulated Kinase 1/2 in Endothelial Cells and Tissue Explants [R] . Lee, Y. H., Marquez, A. P., Mungunsukh, O., 2010

机译：肝细胞生长因子通过细胞外信号调节激酶1/2在内皮细胞和组织外植体中抑制促纤维化因子血管紧张素II的凋亡

The Tumor Suppressor p53 Inhibits Net, an Effector of Ras/Extracellular Signal-Regulated Kinase Signaling

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