Displacement of Histones at Promoters of Saccharomyces cerevisiae Heat Shock Genes Is Differentially Associated with Histone H3 Acetylation

T. Y. Erkina; A. M. Erkine

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Displacement of Histones at Promoters of Saccharomyces cerevisiae Heat Shock Genes Is Differentially Associated with Histone H3 Acetylation

机译：酿酒酵母热休克基因启动子上的组蛋白位移与组蛋白H3乙酰化差异相关

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Chromatin remodeling at promoters of activated genes spans from mild histone modifications to outright displacement of nucleosomes in trans. Factors affecting these events are not always clear. Our results indicate that histone H3 acetylation associated with histone displacement differs drastically even between promoters of such closely related heat shock genes as HSP12, SSA4, and HSP82. The HSP12 promoter, with the highest level of histone displacement, showed the highest level of H3 acetylation, while the SSA4 promoter, with a lower histone displacement, showed only modest H3 acetylation. Moreover, for the HSP12 promoter, the level of acetylated H3 is temporarily increased prior to nucleosome departure. Individual promoters in strains expressing truncated versions of heat shock factor (HSF) showed that deletion of either one of two activating regions in HSF led to the diminished histone displacement and correspondingly lower H3 acetylation. The deletion of both regions simultaneously severely decreased histone displacement for all promoters tested, showing the dependence of these processes on HSF. The level of histone H3 acetylation at individual promoters in strains expressing truncated HSF also correlated with the extent of histone displacement. The beginning of chromatin remodeling coincides with the polymerase II loading on heat shock gene promoters and is regulated either by HSF binding or activation of preloaded HSF.

机译：活化基因启动子的染色质重塑范围从轻微的组蛋白修饰到 trans 中核小体的完全置换。影响这些事件的因素并不总是很清楚。我们的结果表明，与组蛋白置换相关的组蛋白H3乙酰化差异很大，即使在与 HSP12 ， SSA4 和 HSP82 。具有最高组蛋白置换水平的 HSP12 启动子显示出最高水平的H3乙酰化，而具有较低组蛋白置换的 SSA4 启动子具有仅少量的H3乙酰化。。此外，对于 HSP12 启动子，乙酰化H3的水平在核小体离开之前暂时增加。表达热休克因子（HSF）截短形式的菌株中的个别启动子显示，HSF中两个激活区域之一的缺失导致组蛋白置换减少，并相应降低了H3乙酰化。对于所有测试的启动子，两个区域的缺失同时严重降低了组蛋白置换，显示了这些过程对HSF的依赖性。表达截短的HSF的菌株中各个启动子的组蛋白H3乙酰化水平也与组蛋白置换的程度有关。染色质重塑的开始与热激基因启动子上聚合酶II的加载相一致，并受HSF结合或预加载HSF激活的调节。 展开▼

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《Molecular and Cellular Biology》 |2006年第20期|共14页

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T. Y. Erkina; A. M. Erkine;
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中图分类细胞生物学;

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1. Histone H3K4 demethylation is negatively regulated by histone H3 acetylation in Saccharomyces cerevisiae [J] . Vicki E. Maltby, Benjamin J. E. Martin, Julie BrindAmour, Proceedings of the National Academy of Sciences of the United States of America . 2012,第45期

机译：酿酒酵母中组蛋白H3乙酰化对组蛋白H3K4脱甲基的调节

2. EZH2 and histone deacetylase inhibitors induce apoptosis in triple negative breast cancer cells by differentially increasing H3 Lys(27) acetylation in the BIM gene promoter and enhancers [J] . Huang Julia P., Ling Kun Oncology letters . 2017,第5aPta2期

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3. Nano-electrospray tandem mass spectrometric analysis of the acetylation state of histones H3 and H4 in stationary phase in Saccharomyces cerevisiae [J] . Mzwanele Ngubo, Gabr#233, Kemp, BMC Biochemistry . 2011,第1期

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4. The analysis on the combinations of histone modifications at the promoter region of gene in Saccharomyces.cerevisiae [C] . Xiangjun Cui, Hong Li 2011 International Conference on Remote Sensing, Environment and Transportation Engineering . 2011

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5. Regulation of human cytomegalovirus gene expression by changes in histone H3 acetylation and methylation, and through binding of transcription factors to promoter regions during replication in fibroblasts. [D] . Cuevas, Christian David. 2009

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6. Displacement of Histones at Promoters of Saccharomyces cerevisiae Heat Shock Genes Is Differentially Associated with Histone H3 Acetylation [O] . T. Y. Erkina, A. M. Erkine 2006

机译：酿酒酵母热休克基因启动子上的组蛋白位移与组蛋白H3乙酰化差异相关

7. Displacement of Histones at Promoters of Saccharomyces cerevisiae Heat Shock Genes Is Differentially Associated with Histone H3 Acetylation [O] . Erkina, T. Y., Erkine, A. M. 2006

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4. '' method for producing a saccharomyces cerevisiae strain with introduced genes encoding xylose reductase, xylitol dehydrogenase and xylulokinase and with enhanced ethanol production, enhanced xylose conversion and reduced axitol production, introduced saccharomyces cerevisiae strain encoding xylose reductase , with enhanced ethanol production, xylitol dehydrogenase and xylulokinase, enhanced xylose conversion and reduced xylitol production, enhanced ethanol producing saccharomyces cerevisiae strain, enhanced xylose conversion and reduced xylitol production, ethanol producing saccharomyces cerevisiae strain enhanced xylose conversion, reduced xylitol production, enhanced ethanol producing saccaromyces cerevisiae strain, enhanced xylose conversion, enhanced ethanol production, reduced xylitol production, and increased inhibitor tolerance and use of a '' strain [P] . 外国专利： BR112013011815A2 . 2017-10-31

机译：''生产具有引入的编码木糖还原酶，木糖醇脱氢酶和木酮糖酶基因的酿酒酵母菌株的方法，并具有增强的乙醇产量，增强的木糖转化率和减少的木糖醇产量，引入引入的编码木糖还原酶的酿酒酵母菌株，增强的乙醇产量，木糖醇脱氢酶和木酮糖激酶，提高的木糖转化率和降低的木糖醇产量，提高的乙醇生产酵母菌菌株，提高的木糖转化率和减少的木糖醇产量，乙醇生产的酿酒酵母菌株，增强的木糖转化率，降低的木糖醇产量，提高的乙醇生产酵母菌，提高的木糖酵母转化率，提高的木糖转化率，乙醇生产，木糖醇生产减少，抑制剂耐受性提高和使用''菌株

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机译：使用选自以下的化合物：蛋白酶体抑制剂，自噬抑制剂，溶酶体抑制剂，高尔基体蛋白转运抑制剂，hsp90伴侣蛋白抑制剂，热休克反应激活剂，α和组蛋白脱乙酰酶抑制剂，使用11 -顺式-视黄醛或9-顺式-视黄醛以及选自蛋白酶体抑制剂，自噬抑制剂，核糖体抑制剂，高尔基体蛋白er，hsp90伴侣蛋白抑制剂，热休克反应激活剂，糖苷酶的化合物抑制剂和组蛋白脱乙酰基酶抑制剂，一种增加细胞中蛋白质的生化功能构象量的方法，用于治疗眼pcd的组合物药物，用于治疗色素性视网膜炎的药物组合物，用于治疗视网膜色素变性的试剂盒眼用pcd，用于治疗色素性视网膜炎的试剂盒，用于鉴定可用于治疗具有眼用pcd的个体的化合物的方法，

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Displacement of Histones at Promoters of Saccharomyces cerevisiae Heat Shock Genes Is Differentially Associated with Histone H3 Acetylation

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