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首页> 外文期刊>Molecular and Cellular Biology >Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs.
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Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs.

机译：骨形态发生蛋白（BMP）的人类II型受体：将二激酶受体模型扩展到BMP。

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Bone morphogenic proteins (BMPs) are universal regulators of animal development. We report the identification and cloning of the BMP type II receptor (BMPR-II), a missing component of this receptor system in vertebrates. BMPR-II is a transmembrane serine/threonine kinase that binds BMP-2 and BMP-7 in association with multiple type I receptors, including BMPR-IA/Brk1, BMPR-IB, and ActR-I, which is also an activin type I receptor. Cloning of BMPR-II resulted from a strong interaction of its cytoplasmic domain with diverse transforming growth factor beta family type I receptor cytoplasmic domains in a yeast two-hybrid system. In mammalian cells, however, the interaction of BMPR-II is restricted to BMP type I receptors and is ligand dependent. BMPR-II binds BMP-2 and -7 on its own, but binding is enhanced by coexpression of type I BMP receptors. BMP-2 and BMP-7 can induce a transcriptional response when added to cells coexpressing ActR-I and BMPR-II but not to cells expressing either receptor alone. The kinase activity of both receptors is essential for signaling. Thus, despite their ability to bind to type I and II receptors receptors separately, BMPs appear to require the cooperation of these two receptors for optimal binding and for signal transduction. The combinatorial nature of these receptors and their capacity to crosstalk with the activin receptor system may underlie the multifunctional nature of their ligands.
机译：骨形态发生蛋白（BMP）是动物发育的通用调节剂。我们报告鉴定和克隆的BMP II型受体（BMPR-II），在脊椎动物中该受体系统的缺失组成部分。 BMPR-II是跨膜丝氨酸/苏氨酸激酶，结合多种I型受体（包括BMPR-IA / Brk1，BMPR-IB和ActR-I）结合BMP-2和BMP-7，后者也是I型激活素。受体。 BMPR-II的克隆是由于其胞质结构域与酵母双杂交系统中各种转化生长因子β家族I受体I胞质结构域的强烈相互作用而引起的。但是，在哺乳动物细胞中，BMPR-II的相互作用仅限于I型BMP受体，并且是配体依赖性的。 BMPR-II自身与BMP-2和-7结合，但I型BMP受体的共表达增强了结合。将BMP-2和BMP-7添加到共表达ActR-I和BMPR-II的细胞中但不添加到单独表达任一受体的细胞中时，可以诱导转录反应。两种受体的激酶活性对于信号传导都是必不可少的。因此，尽管它们具有分别结合I型和II型受体受体的能力，但BMP似乎需要这两个受体的协同作用才能实现最佳结合和信号转导。这些受体的组合性质及其与激活素受体系统发生串扰的能力可能是其配体的多功能性质的基础。

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