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Immunological Development and Cardiovascular Function Are Normal in Annexin VI Null Mutant Mice

机译：Annexin VI空突变小鼠的免疫学发育和心血管功能正常

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Annexins are calcium-binding proteins of unknown function but which are implicated in important cellular processes, including anticoagulation, ion flux regulation, calcium homeostasis, and endocytosis. To gain insight into the function of annexin VI, we performed targeted disruption of its gene in mice. Matings between heterozygous mice produced offspring with a normal Mendelian pattern of inheritance, indicating that the loss of annexin VI did not interfere with viability in utero. Mice lacking annexin VI reached sexual maturity at the same age as their normal littermates, and both males and females were fertile. Because of interest in the role of annexin VI in cardiovascular function, we examined heart rate and blood pressure in knockout and wild-type mice and found these to be identical in the two groups. Similarly, the cardiovascular responses of both sets of mice to septic shock were indistinguishable. We also examined components of the immune system and found no differences in thymic, splenic, or bone marrow lymphocyte levels between knockout and wild-type mice. This is the first study of annexin knockout mice, and the lack of a clear phenotype has broad implications for current views of annexin function.
机译：膜联蛋白是功能未知的钙结合蛋白，但与重要的细胞过程有关，包括抗凝，离子通量调节，钙稳态和内吞作用。为了深入了解膜联蛋白VI的功能，我们在小鼠中进行了有针对性的基因破坏。杂合小鼠之间的交配产生了具有正常孟德尔遗传模式的后代，这表明膜联蛋白VI的缺失不会干扰子宫内的活力。缺乏膜联蛋白VI的小鼠与正常同窝同龄的动物达到了性成熟，雄性和雌性都可以生育。由于对膜联蛋白VI在心血管功能中的作用感兴趣，我们检查了基因敲除和野生型小鼠的心率和血压，发现两组小鼠中的心率和血压相同。同样，两组小鼠对败血性休克的心血管反应也无法区分。我们还检查了免疫系统的组成部分，发现基因敲除小鼠和野生型小鼠的胸腺，脾脏或骨髓淋巴细胞水平无差异。这是对膜联蛋白基因敲除小鼠的首次研究，缺乏清晰的表型对膜联蛋白功能的当前观点具有广泛的意义。

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