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首页> 外文期刊>Molecular and Cellular Biology >NF-κB Activates Prostate-Specific Antigen Expression and Is Upregulated in Androgen-Independent Prostate Cancer
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NF-κB Activates Prostate-Specific Antigen Expression and Is Upregulated in Androgen-Independent Prostate Cancer

机译：NF-κB激活前列腺特异性抗原表达，并在雄激素非依赖性前列腺癌中上调。

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The transcription factor NF-κB regulates gene expression involved in cell growth and survival and has been implicated in progression of hormone-independent breast cancer. By expressing a dominant-active form of mitogen-activated protein kinase kinase kinase 1, by exposure to tumor necrosis factor alpha, or by overexpression of p50/p65, we show that NF-κB activates a transcription regulatory element of the prostate-specific antigen (PSA)-encoding gene, a marker for prostate cancer development, treatment, and progression. By DNase I footprinting, we identified four NF-κB binding sites in the PSA core enhancer. We also demonstrate that androgen-independent prostate cancer xenografts have higher constitutive NF-κB binding activity than their androgen-dependent counterparts. These results suggest a role of NF-κB in prostate cancer progression.
机译：转录因子NF-κB调节与细胞生长和存活有关的基因表达，并与激素非依赖性乳腺癌的进展有关。通过表达有丝分裂原激活的蛋白激酶激酶激酶1的显性活性形式，通过暴露于肿瘤坏死因子α或通过p50 / p65的过表达，我们显示NF-κB激活了前列腺特异性抗原的转录调控元件（PSA）编码基因，是前列腺癌发展，治疗和进展的标记。通过DNase I足迹，我们在PSA核心增强子中鉴定了四个NF-κB结合位点。我们还证明，雄激素非依赖性前列腺癌异种移植物比其雄激素依赖性对应物具有更高的组成型NF-κB结合活性。这些结果表明NF-κB在前列腺癌进展中的作用。

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