Coexpression of two closely linked avian genes for purine nucleotide synthesis from a bidirectional promoter.

A Gavalas; J E Dixon; K A Brayton; H Zalkin

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Coexpression of two closely linked avian genes for purine nucleotide synthesis from a bidirectional promoter.

机译：从双向启动子共表达两个嘌呤核苷酸合成的紧密联系的禽类基因。

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Two avian genes encoding essential steps in the purine nucleotide biosynthetic pathway are transcribed divergently from a bidirectional promoter element. The bidirectional promoter, embedded in a CpG island, directs coexpression of GPAT and AIRC genes from distinct transcriptional start sites 229 bp apart. The bidirectional promoter can be divided in half, with each half retaining partial activity towards the cognate gene. GPAT and AIRC genes encode the enzymes that catalyze step 1 and steps 6 plus 7, respectively, in the de novo purine biosynthetic pathway. This is the first report of genes coding for structurally unrelated enzymes of the same pathway that are tightly linked and transcribed divergently from a bidirectional promoter. This arrangement has the potential to provide for regulated coexpression comparable to that in a prokaryotic operon.

机译：从双向启动子元件发散地转录了编码嘌呤核苷酸生物合成途径中必需步骤的两个禽类基因。嵌入CpG岛中的双向启动子指导GPAT和AIRC基因从相距229 bp的不同转录起始位点共表达。双向启动子可分为两半，每半保留对同源基因的部分活性。 GPAT和AIRC基因编码从头嘌呤生物合成途径中分别催化步骤1和步骤6加7的酶。这是关于编码同一途径中结构无关的酶的基因的首次报道，该酶紧密连接并从双向启动子发散地转录。这种安排有可能提供与原核操纵子相比可调节的共表达。

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《Molecular and Cellular Biology》 |1993年第8期|共9页
作者
A Gavalas; J E Dixon; K A Brayton; H Zalkin;
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中图分类细胞生物学;
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1. De novo purine nucleotide biosynthesis: cloning of human and avian cDNAs encoding the trifunctional glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase by functional complementation in E.coli [J] . Hong Qiu, Howard Zalkin, Jack E. Dixon, Nucleic acids research . 1990,第22期

机译：从头进行嘌呤核苷酸的生物合成：通过大肠杆菌中的功能互补来克隆编码三功能甘氨酰胺核糖核苷酸合成酶-氨基咪唑核糖核苷酸合成酶-甘氨酰胺核糖核苷酸转化酶的人和禽cDNA
2. Effects of limiting different purine nucleotide precursors on nucleic acid synthesis and nucleotide pools of purine-requiring mutants of Escherichia coli [J] . G A Jeffries, K Burton The biochemical journal . 1969,第2期

机译：限制不同嘌呤核苷酸前体对大肠杆菌嘌呤突变体核酸合成和核苷酸库的影响
3. A Link Between Impaired Purine Nucleotide Synthesis and Apoptosis in Drosophila melanogaster [J] . Holland Catherine, Lipsett David B., Clark Denise V. Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation . 2011,第2期

机译：果蝇嘌呤核苷酸合成受损与细胞凋亡之间的联系。
4. Differentiation of Highly Pathogenic Avian Influenza Virus (HPAIV) A strains using of GB-speckles, generated for the nucleotide sequences of the neuraminidase gene [C] . Maria Khizhnyakova, Sergey Zaytsev, Nadezhda Filonova, Saratov Meeting: Optical and Nanotechnologies for Biology and Medicine . 2020

机译：高致病性禽流感病毒（HPAIV）的差异，用于使用GB斑点的菌株，为神经氨酸酶基因的核苷酸序列产生
5. Modification of pyrimidine and purine nucleotides by "click" chemistry: Design, synthesis and properties study. [D] . Haque, Mohammad Mojibul. 2014

机译：通过“点击”化学修饰嘧啶和嘌呤核苷酸：设计，合成和性质研究。
6. Coexpression of two closely linked avian genes for purine nucleotide synthesis from a bidirectional promoter. [O] . A Gavalas, J E Dixon, K A Brayton, 1993

机译：从双向启动子共表达两个嘌呤核苷酸合成的紧密联系的禽类基因。
7. Coexpression of two closely linked avian genes for purine nucleotide synthesis from a bidirectional promoter. [O] . Gavalas, A, Dixon, J E, Brayton, K A, 1993

机译：从双向启动子共表达两个嘌呤核苷酸合成的紧密联系的禽类基因。
8. Use of Exogenous Purines and Purine Nucleotides in the Biosynthesis of Nucleic Acids in Plague Bacteria [R] . Maiskii, V. G. 1969

机译：外源嘌呤和嘌呤核苷酸在鼠疫细菌核酸生物合成中的应用

Coexpression of two closely linked avian genes for purine nucleotide synthesis from a bidirectional promoter.

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