NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli.

J Svaren; B R Sevetson; E D Apel; D B Zimonjic; N C Popescu; J Milbrandt

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NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli.

机译：NAB2是NGFI-A（Egr-1）和Krox20的核心抑制剂，是由增殖和分化刺激所诱导的。

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Previous work had identified a corepressor, NAB1, which represses transcriptional activation mediated by NGFI-A (also known as Egr-1, zif268, and Krox24) and Krox20. These zinc finger transcription factors are encoded by immediate-early genes and have been implicated in a wide variety of proliferative and differentiative processes. We have isolated and characterized another corepressor, NAB2, which is highly related to NAB1 within two discrete domains. The first conserved domain of NAB2 mediates an interaction with the R1 domain of NGFI-A. NAB2 represses the activity of both NGFI-A and Krox20, and its expression is regulated by some of the same stimuli that induce NGFI-A expression, including serum stimulation of fibroblasts and nerve growth factor stimulation of PC12 cells. The human NAB2 gene has been localized to chromosome 12ql3.3-14.1, a region that is rearranged in several solid tumors, lipomas, uterine leiomyomata, and liposarcomas. Sequencing of the Caenorhabditis elegans genome has identified a gene that bears high homology to both NAB1 and NAB2, suggesting that NAB molecules fulfill an evolutionarily conserved role.

机译：先前的工作已确定了NAB1核心抑制剂，NAB1抑制由NGFI-A（也称为Egr-1，zif268和Krox24）和Krox20介导的转录激活。这些锌指转录因子由立即早期基因编码，并已涉及多种增殖和分化过程。我们已经分离并鉴定了另一种核心抑制剂NAB2，它在两个离散域中与NAB1高度相关。 NAB2的第一个保守域介导与NGFI-A的R1域的相互作用。 NAB2抑制NGFI-A和Krox20的活性，其表达受到诱导NGFI-A表达的某些相同刺激的调节，包括血清刺激成纤维细胞和神经生长因子刺激PC12细胞。人类NAB2基因已定位于染色体12ql3.3-14.1，该区域在几种实体瘤，脂肪瘤，子宫平滑肌瘤和脂肪肉瘤中重排。秀丽隐杆线虫基因组的测序已鉴定出与NAB1和NAB2都具有高度同源性的基因，表明NAB分子具有进化上保守的作用。

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《Molecular and Cellular Biology》 |1996年第7期|共9页
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J Svaren; B R Sevetson; E D Apel; D B Zimonjic; N C Popescu; J Milbrandt;
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1. NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli. [J] . J Svaren, B R Sevetson, E D Apel, Molecular and Cellular Biology . 1996,第7期

机译：NAB2是NGFI-A（Egr-1）和Krox20的核心抑制剂，是由增殖和分化刺激所诱导的。
2. Nab1, a Corepressor of NGFI-A (Egr-1), Contains an Active Transcriptional Repression Domain [J] . Alexander H. Swirnoff, Elizabeth D. Apel, John Svaren, Molecular and Cellular Biology . 1998,第1期

机译：Nab1，NGFI-A（Egr-1）的核心抑制剂，包含一个主动转录抑制域。
3. Nocturnal light pulses selectively induce Egr-1/NGFI-A protein in periventricular hypophysiotrophic somatostatinergic neurons. [J] . Slade JP, Knight C, Carter D Journal of Molecular Neuroscience: MN . 2001,第3期

机译：夜间光脉冲在心室周围营养不良的生长抑素能神经元中选择性诱导Egr-1 / NGFI-A蛋白。
4. Egr-1 expression induced by ZnO nanoparticles in human keratinocytes [C] . Sang Hoon Jeong, Hwa Jung Ryu, Yoon-Hee Park, 2012 12th IEEE International Conference on Nanotechnology. . 2012

机译：ZnO纳米颗粒在人角质形成细胞中诱导的Egr-1表达
5. Granulocyte colony -stimulating factor induces egr-1 up-regulation in myeloid cells through a MEK/ERK-dependent pathway and through interaction of serum response element -binding proteins [D] . Mora-Garcia, Patricia 2002

机译：粒细胞集落刺激因子通过MEK / ERK依赖性途径以及血清反应因子结合蛋白的相互作用诱导髓样细胞中的egr-1上调。
6. NAB2 a corepressor of NGFI-A (Egr-1) and Krox20 is induced by proliferative and differentiative stimuli. [O] . J Svaren, B R Sevetson, E D Apel, 1996

机译：NAB2是NGFI-A（Egr-1）和Krox20的核心抑制剂是由增殖性和分化性刺激诱导的。
7. NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli. [O] . Svaren, J, Sevetson, B R, Apel, E D, 1996

机译：NAB2是NGFI-A（Egr-1）和Krox20的核心抑制剂，是由增殖性和分化性刺激诱导的。

NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli.

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