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The Caenorhabditis elegans Nuclear Receptor Gene nhr-25 Regulates Epidermal Cell Development

机译：秀丽隐杆线虫核受体基因nhr-25调节表皮细胞发育

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The development of the epidermis of Caenorhabditis elegans involves cell fusion, migration, and differentiation events. To understand the mechanisms underlying these processes, we characterized the roles of NHR-25, a member of the nuclear receptor family of transcription factors. The NHR-25 homologs Ftz-F1 in Drosophila and SF-1 in mammals are involved in various biological processes, including regulation of patterning during development, reproduction, metabolism, metamorphosis, and homeostasis. Impairment of nhr-25 activity leads to severe phenotypes in embryos and many postembryonic tissues. Further analysis has indicated that nhr-25 activity is required for the proper development, including cell-cell fusion, of several epidermal cell types, such as the epidermal syncytial, seam, and Pn.p cells. Our results also suggest that nhr-25 is likely to regulate cell-cell junctions and/or fusion. In a subset of Pn.p cells, called vulval precursor cells, nhr-25 acts collaboratively with the lin-39 Hox gene in regulating vulval cell differentiation. Additionally, our data suggest that nhr-25 may also function with another Hox gene, nob-1, during embryogenesis. Overall, our results indicate that nhr-25 plays an integral role in regulating cellular processes of epidermal cells.
机译：秀丽隐杆线虫表皮的发育涉及细胞融合，迁移和分化事件。为了解这些过程的潜在机制，我们表征了NHR-25（转录因子核受体家族的成员）的作用。果蝇中的NHR-25同源蛋白Ftz-F1和哺乳动物中的SF-1参与了各种生物学过程，包括发育，繁殖，代谢，变态和体内平衡过程中的模式调节。 nhr-25 活性受损会导致胚胎和许多胚后组织出现严重的表型。进一步的分析表明， nhr-25 活性对于几种表皮细胞类型（例如表皮合胞体，接缝和Pn.p细胞）的正常发育（包括细胞-细胞融合）是必需的。我们的结果还表明， nhr-25 可能调节细胞-细胞连接和/或融合。在称为外阴前体细胞的Pn.p细胞子集中， nhr-25 与 lin-39 Hox基因协同作用调节外阴细胞分化。此外，我们的数据表明， nhr-25 在胚胎发生过程中也可能与另一个Hox基因 nob-1 一起起作用。总体而言，我们的结果表明 nhr-25 在调节表皮细胞的细胞过程中起着不可或缺的作用。

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