awd, the Homolog of Metastasis Suppressor Gene Nm23, Regulates Drosophila Epithelial Cell Invasion

Gouthami Nallamothu; Julie A. Woolworth; Vincent Dammai; Tien Hsu

首页> 外文期刊>Molecular and Cellular Biology >awd, the Homolog of Metastasis Suppressor Gene Nm23, Regulates Drosophila Epithelial Cell Invasion

【24h】

awd, the Homolog of Metastasis Suppressor Gene Nm23, Regulates Drosophila Epithelial Cell Invasion

机译：awd，转移抑制基因Nm23的同源物，调节果蝇上皮细胞的侵袭

获取原文

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Border cell migration during Drosophila melanogaster oogenesis is a highly pliable model for studying epithelial to mesenchymal transition and directional cell migration. The process involves delamination of a group of 6 to 10 follicle cells from the epithelium followed by guided migration and invasion through the nurse cell complex toward the oocyte. The guidance cue is mainly provided by the homolog of platelet-derived growth factor/vascular endothelial growth factor family of growth factor, or Pvf, emanating from the oocyte, although Drosophila epidermal growth factor receptor signaling also plays an auxiliary role. Earlier studies implicated a stringent control of the strength of Pvf-mediated signaling since both down-regulation of Pvf and overexpression of active Pvf receptor (Pvr) resulted in stalled border cell migration. Here we show that the metastasis suppressor gene homolog Nm23/awd is a negative regulator of border cell migration. Its down-regulation allows for optimal spatial signaling from two crucial pathways, Pvr and JAK/STAT. Its overexpression in the border cells results in stalled migration and can revert the phenotype of overexpressing constitutive Pvr or dominant-negative dynamin. This is a rare example demonstrating the relevance of a metastasis suppressor gene function utilized in a developmental process involving cell invasion.

机译：果蝇卵生过程中的边界细胞迁移是研究上皮到间质转化和定向细胞迁移的高度灵活的模型。该过程涉及从上皮中剥离一组6至10个卵泡细胞，然后通过护士细胞复合物向卵母细胞进行定向迁移和侵袭。指导提示主要由卵母细胞产生的血小板衍生生长因子/血管内皮生长因子家族的生长因子或Pvf的同源物提供，尽管果蝇表皮生长因子受体信号传导也发挥了作用。辅助作用。较早的研究暗示严格控制Pvf介导的信号传导，因为Pvf的下调和活性Pvf受体（Pvr）的过表达都导致停滞的边界细胞迁移。在这里，我们显示了转移抑制基因同源物 Nm23 / awd 是边界细胞迁移的负调节剂。它的下调允许来自两个关键途径Pvr和JAK / STAT的最佳空间信号传导。它在边界细胞中的过度表达导致迁移停滞，并且可以还原过度表达的组成型Pvr或显性负性动力蛋白的表型。这是一个罕见的例子，证明了在涉及细胞侵袭的发育过程中使用的转移抑制基因功能的相关性。 展开▼

著录项

来源
《Molecular and Cellular Biology》 |2008年第6期|共10页

作者
Gouthami Nallamothu; Julie A. Woolworth; Vincent Dammai; Tien Hsu;
展开▼

作者单位

展开▼

收录信息

原文格式 PDF

正文语种

中图分类细胞生物学;

关键词

相似文献

外文文献

中文文献

专利

1. The Drosophila Metastasis Suppressor Gene Nm23 Homolog, awd, Regulates Epithelial Integrity during Oogenesis [J] . Julie A. Woolworth, Gouthami Nallamothu, Tien Hsu Molecular and Cellular Biology . 2009,第17期

机译：果蝇转移抑制基因Nm23同源，awd调节卵子发生过程中的上皮完整性。

2. Notch signaling during development requires the function of awd, the Drosophila homolog of human metastasis suppressor gene Nm23 [J] . Marilena Ignesti, Marilena Barraco, Gouthami Nallamothu, BMC Biology . 2014,第1期

机译：发育中的Notch信号传导需要awd的功能，awd是人类转移抑制基因Nm23的果蝇同源物

3. Human homolog of Drosophila tumor suppressor Scribble negatively regulates cell-cycle progression from G1 to S phase by localizing at the basolateral membrane in epithelial cells. [J] . Nagasaka K, Nakagawa S, Yano T, Cancer science. . 2006,第11期

机译：果蝇肿瘤抑制物Scribble的人类同源物通过定位在上皮细胞的基底外侧膜中，负调控细胞周期从G1到S期的过程。

4. ERβ regulates miR-21 expression and inhibits invasion and metastasis in cancer cells [C] . Junmei Tian, Zhenzhen Tu, Yueqing Gu Biophotonics and immune responses VII. . 2012

机译：ERβ调节miR-21表达并抑制癌细胞的侵袭和转移

5. A study of human homologs of selected Drosophila genes in human mammary ductal carcinoma, asymmetric cell division of human neural stem cells and a multiplex microsphere bead assay for comparative RNA expression analysis. [D] . Fuja, Tannin J. 2003

机译：对人类乳腺导管癌中所选果蝇基因的人类同源物，人类神经干细胞的不对称细胞分裂以及用于比较RNA表达分析的多重微球珠分析的研究。

6. awd the Homolog of Metastasis Suppressor Gene Nm23 Regulates Drosophila Epithelial Cell Invasion [O] . Gouthami Nallamothu, Julie A. Woolworth, Vincent Dammai, 2008

机译：awd转移抑制基因Nm23的同源物调节果蝇上皮细胞的侵袭

7. awd, the Homolog of Metastasis Suppressor Gene Nm23, Regulates Drosophila Epithelial Cell Invasion▿ † [O] . Nallamothu, Gouthami, Woolworth, Julie A., Dammai, Vincent, 2008

机译：awd，转移抑制基因Nm23的同源物，调节果蝇上皮细胞侵袭▿†

8. Role of Mammalian Homologs of the Drosophila Discs Large 1 (dlg 1) Gene in the Genesis of Epithelial Ovarian Cancer [R] . Adashi, E. Y. 2003

机译：果蝇盘中大型1（dlg 1）基因的哺乳动物同源物在上皮性卵巢癌发生中的作用

1. 与肿瘤转移抑制基因nm23高度同源的nm23—H3b基因的克隆和序… [J] . 江贤鹏 ,刘康达 . 中华医学杂志 . 1994,第011期

2. 肿瘤血管形成和转移抑制基因nm23与肝细胞癌侵袭性关系的研究 [J] . 盛红光 ,张敏 ,姜言明 . 中华普通外科杂志 . 2004,第003期

3. 014人类与果蝇lats肿瘤抑制基因的同源物调节CDC2活性 [J] . . 国际遗传学杂志 . 2001,第002期

4. 肿瘤转移抑制基因nm23蛋白类似物在肝细胞癌中的表达 [J] . 倪灿荣 ,戴益民 . 中华医学杂志 . 1996,第001期

5. Ras同源蛋白A-Ras同源蛋白激酶信号转导途径对上皮细胞紧密连接的调节作用 [J] . 余长松 ,贾刚 ,邓秋红 . 动物营养学报 . 2013,第009期

6. 转移抑制基因nm23-H1与肿瘤微环境诱导的上皮细胞间质化相关性研究 [C] . 赵荣志 ,吴志浩 ,尤嘉琮 . 第13届全国肺癌学术大会 . 2013

7. 转移抑制基因nm23-H1与肿瘤微环境诱导的上皮细胞间质化相关性研究 [A] . 赵荣志 . 2013

1. 一种研究食道癌组织转移抑制基因nm23-H1分期分级微阵列组织芯片 [P] . 中国专利： CN102735839A . 2012-10-17

2. 一种黑腹果蝇肿瘤侵袭模型的建立方法 [P] . 中国专利： CN113100178A . 2021-07-13

3. (54) Title: SUPPRESSION OF CANCER METASTASIS (57) Abstract: Methods are provided for suppressing cancer metastasis. Cancer metastasis is the most common cause of treatment failure and death in cancer patients. Tumor cell invasion and/or migration can be significantly inhibited after fibrillar proteins (rVPl, F-HSA, and F-BSA) treatment in vitro. In addition, rVPl can significantly suppress murine and human breast cancer metastasis and human prostate and ovarian cancer metastasis in vivo while F-HSA can significantly suppress murine breast cancer metastasis. Compositions of fibrillar proteins as anti-cancer metastasis therapeutics and methods of use thereof are provided herein. [P] . 外国专利： IN2012MN01463A . 2012-08-24

机译：（54）标题：抑制癌转移（57）摘要：提供了抑制癌转移的方法。癌症转移是癌症患者治疗失败和死亡的最常见原因。在体外处理原纤维蛋白（rVP1，F-HSA和F-BSA）后，肿瘤细胞的侵袭和/或迁移可以得到显着抑制。另外，rVP1可以在体内显着抑制鼠和人乳腺癌的转移以及人前列腺和卵巢癌的转移，而F-HSA可以显着地抑制鼠的乳腺癌的转移。本文提供了作为抗癌转移治疗剂的原纤维蛋白的组合物及其使用方法。

4. ccr5 antagonist, method for determining whether a human individual having prostate cancer is suffering from or at risk of metastasis, to identify a ccr5 antagonist, method for determining whether a human individual having prostate cancer is suffering from or under risk of developing metastasis, to identify a candidate compound, to produce in vitro primary epithelial cells, to diagnose prostate cancer, to select a treatment for an individual having a prostate cancer / tumor, cell line, and, animal model [P] . 外国专利： BR112013023050A8 . 2018-09-25

机译：ccr5拮抗剂，用于确定患有前列腺癌的人是否患有转移瘤或处于转移危险中的方法，以鉴定ccr5拮抗剂，用于确定患有前列腺癌的人的个体患有转移瘤或处于转移危险中的方法，以鉴定一种候选化合物，用于产生体外原代上皮细胞，诊断前列腺癌，为患有前列腺癌/肿瘤，细胞系和动物模型的个体选择治疗方法

5. Tumor cells having tumorigenic potential but lacking invasive/metastatic potential, method for preparing them and screening method for metastasis-related genes using the same [P] . 外国专利： US6767700B2 . 2004-07-27

机译：具有致瘤潜力但缺乏侵袭/转移潜力的肿瘤细胞，其制备方法和使用该肿瘤细胞的转移相关基因的筛选方法

相关主题

awd, the Homolog of Metastasis Suppressor Gene Nm23, Regulates Drosophila Epithelial Cell Invasion

摘要

著录项

相似文献

相关主题

期刊订阅