Distinct retinoid X receptor-retinoic acid receptor heterodimers are differentially involved in the control of expression of retinoid target genes in F9 embryonal carcinoma cells.

H Chiba; J Clifford; D Metzger; P Chambon

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Distinct retinoid X receptor-retinoic acid receptor heterodimers are differentially involved in the control of expression of retinoid target genes in F9 embryonal carcinoma cells.

机译：不同的类视黄醇X受体-视黄酸受体异二聚体在F9胚胎癌细胞中差异性参与类视黄醇靶基因的表达控制。

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The F9 murine embryonal carcinoma cell line represents a well-established system for the study of retinoid signaling in vivo. We have investigated the functional specificity of different retinoid X receptor (RXR)-retinoic acid (RA) receptor (RAR) isotype pairs for the control of expression of endogenous RA-responsive genes, by using wild-type (WT), RXR alpha(-/-), RAR alpha(-/-), RAR gamma(-/-), RXR alpha(-/-)-RAR alpha(-/-), and RXR alpha(-/-)-RAR gamma(-/-) F9 cells, as well as panRXR and RAR isotype (alpha, beta, and gamma)-selective retinoids. We show that in these cells the control of expression of different sets of RA-responsive genes is preferentially mediated by distinct RXR-RAR isotype combinations. Our data support the conclusion that RXR-RAR heterodimers are the functional units transducing the retinoid signal and indicate in addition that these heterodimers exert both specific and redundant functions on the expression of particular sets of RA-responsive genes. We also show that the presence of a given receptor isotype can hinder the activity of another isotype and therefore that functional redundancy between retinoid receptor isotypes can be artifactually generated by gene knockouts.

机译：F9鼠胚胎癌细胞系代表了一种成熟的系统，用于体内类视色素的信号传导研究。我们已经研究了不同类视黄醇X受体（RXR）-视黄酸（RA）受体（RAR）同种型对通过使用野生型（WT），RXR alpha（ -/-），RAR alpha（-/-），RAR gamma（-/-），RXR alpha（-/-）-RAR alpha（-/-）和RXR alpha（-/-）-RAR gamma（- /-）F9细胞，以及panRXR和RAR同种型（α，β和γ）选择性类维生素A。我们显示，在这些细胞中，不同的RA反应基因的不同表达控制集优先由不同的RXR-RAR同种型介导。我们的数据支持以下结论：RXR-RAR异二聚体是转导类维生素A信号的功能单元，并表明这些异二聚体对特定组的RA反应性基因的表达具有特异性和冗余性。我们还表明，给定受体同种型的存在会阻碍另一种同种型的活性，因此类维生素A受体同种型之间的功能冗余可以通过基因敲除人为地产生。

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《Molecular and Cellular Biology》 |1997年第6期|共8页
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H Chiba; J Clifford; D Metzger; P Chambon;
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中图分类细胞生物学;
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1. A dynamic balance between ARP-1/COUP-TFII, EAR-3/COUP-TFI, and retinoic acid receptor:retinoid X receptor heterodimers regulates Oct-3/4 expression in embryonal carcinoma cells. [J] . E Ben-Shushan, H Sharir, E Pikarsky, Molecular and Cellular Biology . 1995,第2期

机译：ARP-1 / COUP-TFII，EAR-3 / COUP-TFI和视黄酸受体：类维生素X受体异二聚体之间的动态平衡调节胚胎癌细胞中Oct-3 / 4的表达。
2. Retinoic acid induction of major histocompatibility complex class I genes in NTera-2 embryonal carcinoma cells involves induction of NF-kappa B (p50-p65) and retinoic acid receptor beta-retinoid X receptor beta heterodimers. [J] . J H Segars, T Nagata, V Bours, Molecular and Cellular Biology . 1993,第10期

机译：维甲酸在NTera-2胚胎癌细胞中诱导主要的组织相容性复合体I类基因涉及诱导NF-κB（p50-p65）和视黄酸受体β-类维生素X受体β异二聚体。
3. Expression of retinoid receptors during the retinoic acid-induced neuronal differentiation of human embryonal carcinoma cells. [J] . Cheung WM, Chu PW, Lung CH, Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry . 2000,第1期

机译：维甲酸诱导人类胚胎癌细胞神经元分化过程中类维生素A受体的表达。
4. Characterization of the zinc finger gene Rex-1 (Zfp-42) whose expression is reduced in murine F9 embryonal carcinoma cells treated with retinoic acid. [D] . Hosler, Betsy Ann. 1993

机译：锌指基因Rex-1（Zfp-42）的表征，在用视黄酸处理的小鼠F9胚胎癌细胞中其表达降低。
5. Distinct retinoid X receptor-retinoic acid receptor heterodimers are differentially involved in the control of expression of retinoid target genes in F9 embryonal carcinoma cells. [O] . H Chiba, J Clifford, D Metzger, 1997

机译：不同的类视黄醇X受体-视黄酸受体异二聚体在F9胚胎癌细胞中差异性参与类视黄醇靶基因的表达控制。
6. Distinct retinoid X receptor-retinoic acid receptor heterodimers are differentially involved in the control of expression of retinoid target genes in F9 embryonal carcinoma cells. [O] . Chiba, H, Clifford, J, Metzger, D, 1997

机译：不同的类视黄醇X受体-视黄酸受体异二聚体在F9胚胎癌细胞中差异性参与类视黄醇靶基因的表达控制。

Distinct retinoid X receptor-retinoic acid receptor heterodimers are differentially involved in the control of expression of retinoid target genes in F9 embryonal carcinoma cells.

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