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Notch and Wingless Regulate Expression of Cuticle Patterning Genes

机译：切口和无翅调节表皮模式基因的表达。

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The cell surface receptor Notch is required duringDrosophila embryogenesis for production of epidermal precursor cells. The secreted factor Wingless is required for specifying different types of cells during differentiation of tissues from these epidermal precursor cells. The results reported here show that the full-length Notch and a form of Notch truncated in the amino terminus associate with Wingless in S2 cells and in embryos. In S2 cells, Wingless and the two different forms of Notch regulate expression of Dfrizzled 2, a receptor of Wg;hairy, a negative regulator of achaeteexpression; shaggy, a negative regulator ofengrailed expression; and patched, a negative regulator of wingless expression. Analyses of expression of the same genes in mutant N embryos indicate that the pattern of gene regulations observed in vitro reflects regulations in vivo. These results suggest that the strong genetic interactions observed between Notch and wingless genes during development of Drosophila is at least partly due to regulation of expression of cuticle patterning genes by Wingless and the two forms of Notch.
机译：果蝇胚胎发生过程中需要细胞表面受体Notch来产生表皮前体细胞。从这些表皮前体细胞分化组织期间，需要分泌因子Wingless来指定不同类型的细胞。此处报道的结果表明，全长Notch和在氨基末端截短的Notch形式与S2细胞和胚胎中的Wingless相关。在S2细胞中，Wingless和Notch的两种不同形式调节Wg受体 Dfrizzled 2 的表达; achaete 的负调节剂 hairy >表达; shaggy ，参与表达的负调节子;和 patched ，这是 wingless 表达的负向调节器。突变 N 胚胎中相同基因表达的分析表明，体外观察到的基因调控模式反映了体内调控。这些结果表明果蝇发育过程中 Notch 和 wingless 基因之间观察到的强遗传相互作用至少部分是由于表皮表达的调节Wingless和Notch的两种形式对基因进行模式化。

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