Identification and analysis of a functional human homolog of the SPT4 gene of Saccharomyces cerevisiae.

G A Hartzog; M A Basrai; S L Ricupero-Hovasse; P Hieter; F Winston

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Identification and analysis of a functional human homolog of the SPT4 gene of Saccharomyces cerevisiae.

机译：酿酒酵母SPT4基因的功能性人类同源物的鉴定和分析。

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Spt4p is a nonhistone protein of Saccharomyces cerevisiae that is believed to be required for normal chromatin structure and transcription. In this work we describe the isolation and analysis of a human gene, SUPT4H, that encodes a predicted protein 42% identical to Spt4p. When expressed in S. cerevisiae, SUPT4H complemented all spt4 mutant phenotypes. In human cells SUPT4H encodes a nuclear protein that is expressed in all tissues tested. In addition, hybridization analyses suggest that an SUPT4H-related gene is also present in mice. SUPT4H was localized to human chromosome 17 by PCR analysis of a human-rodent somatic cell hybrid panel. Thus, like other proteins that are components of or control the structure of chromatin, Spt4p appears to be conserved from S. cerevisiae to mammals.

机译：Spt4p是酿酒酵母的非组蛋白，被认为是正常染色质结构和转录所必需的。在这项工作中，我们描述了人类基因SUPT4H的分离和分析，该基因编码的预测蛋白与Spt4p具有42％的同一性。当在酿酒酵母中表达时，SUPT4H补充了所有spt4突变表型。在人类细胞中，SUPT4H编码一种在所有测试组织中表达的核蛋白。另外，杂交分析表明SUPT4H相关基因也存在于小鼠中。通过对人-啮齿动物体细胞杂交板的PCR分析，SUPT4H定位于人染色体17。因此，像其他染色质的组成部分或控制染色质结构的其他蛋白质一样，Spt4p似乎从酿酒酵母向哺乳动物保守。

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《Molecular and Cellular Biology》 |1996年第6期|共9页
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G A Hartzog; M A Basrai; S L Ricupero-Hovasse; P Hieter; F Winston;
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中图分类细胞生物学;
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机译：酿酒酵母SPT4基因的功能性人类同源物的鉴定和分析。
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Identification and analysis of a functional human homolog of the SPT4 gene of Saccharomyces cerevisiae.

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