Extracellular Signal-Regulated Protein Kinase 2 Is Required for Efficient Generation of B Cells Bearing Antigen-Specific Immunoglobulin G

Hideki Sanjo; Masaki Hikida; Yuichi Aiba; Yoshiko Mori; Naoya Hatano; Masato Ogata; Tomohiro Kurosaki

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Extracellular Signal-Regulated Protein Kinase 2 Is Required for Efficient Generation of B Cells Bearing Antigen-Specific Immunoglobulin G

机译：有效生成带有抗原特异性免疫球蛋白G的B细胞需要细胞外信号调节蛋白激酶2

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Activation of extracellular signal-regulated protein kinase (ERK) has been implicated in proliferation as well as differentiation in a wide variety of cell types. Using B-cell-specific gene-targeted mice, we report here that in T-cell-dependent immune responses, ERK2 is required to generate efficient immunoglobulin G (IgG) production. In its absence, the proportion of antigen-specific surface IgG1-bearing cells and the subsequent number of IgG1 antibody-secreting cells were decreased, despite apparently unimpaired class switch recombination. Notably, this defect was countered by overexpression of the antiapoptotic factor Bcl-2. Together, our results suggest that ERK2 plays a key role in efficient generation of antigen-specific IgG-bearing B cells by promoting their survival.

机译：细胞外信号调节蛋白激酶（ERK）的激活与多种细胞类型的增殖和分化有关。使用B细胞特异性基因靶向的小鼠，我们在这里报告在依赖T细胞的免疫反应中，需要ERK2才能产生有效的免疫球蛋白G（IgG）。在没有它的情况下，尽管表面转换重组显然没有受到损害，但抗原特异性表面IgG1携带细胞的比例和随后的IgG1抗体分泌细胞的数量却减少了。值得注意的是，该缺陷被抗凋亡因子Bcl-2的过度表达所抵消。在一起，我们的结果表明ERK2通过促进其存活在有效产生抗原特异性IgG的B细胞中起关键作用。

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《Molecular and Cellular Biology》 |2007年第4期|共11页
作者
Hideki Sanjo; Masaki Hikida; Yuichi Aiba; Yoshiko Mori; Naoya Hatano; Masato Ogata; Tomohiro Kurosaki;
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中图分类细胞生物学;
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1. Up-regulation of c-jun mRNA in cardiac myocytes requires the extracellular signal-regulated kinase cascade, but c-Jun N-terminal kinases are required for efficient up-regulation of c-Jun protein. [J] . Clerk A, Kemp TJ, Harrison JG, The Biochemical Journal . 2002,第Pta1期

机译：心肌细胞中c-jun mRNA的上调需要细胞外信号调节的激酶级联反应，但是c-Jun N端激酶是有效上调c-Jun蛋白质所必需的。
2. Up-regulation of c-jun mRNA in cardiac myocytes requires the extracellular signal-regulated kinase cascade, but c-Jun N-terminal kinases are required for efficient up-regulation of c-Jun protein [J] . Clerk A, Kemp TJ, Harrison JG, The Biochemical Journal . 2002,第0期

机译：心肌细胞中c-jun mRNA的上调需要细胞外信号调节的激酶级联反应，而c-Jun N端激酶是有效上调c-Jun蛋白质所必需的
3. Up-regulation of c-jun mRNA in cardiac myocytes requires the extracellular signal-regulated kinase cascade, but c-Jun N-terminal kinases are required for efficient up-regulation of c-Jun protein [J] . Clerk A, Kemp TJ, Harrison JG, The Biochemical Journal . 2002,第Pta1期

机译：心肌细胞中c-jun mRNA的上调需要细胞外信号调节的激酶级联反应，而c-Jun N端激酶是有效上调c-Jun蛋白质所必需的
4. Activation of Androgen Receptor in Prostate Cancer: Role of Protein Kinase A and Extracellular Signal-regulated Kinases [C] . Yehia Daaka, Elizabeth Kasbohm, Charles Yowel International Symposium on Hormonal Carcinogenesis . 2005

机译：前列腺癌中雄激素受体的激活 - 蛋白激酶A和细胞外信号调节激酶的作用
5. RAF-1 kinase inhibitor protein-mediated cholecystokinin-2 receptor desensitization and extracellular signal-regulated kinase activation. [D] . Park, Jeseong. 2009

机译：RAF-1激酶抑制剂蛋白介导的胆囊收缩素2受体脱敏和细胞外信号调节激酶激活。
6. Extracellular Signal-Regulated Protein Kinase 2 Is Required for Efficient Generation of B Cells Bearing Antigen-Specific Immunoglobulin G [O] . Hideki Sanjo, Masaki Hikida, Yuichi Aiba, 2007

机译：有效携带抗原特异性免疫球蛋白G的B细胞需要细胞外信号调节蛋白激酶2
7. Extracellular Signal-Regulated Protein Kinase 2 Is Required for Efficient Generation of B Cells Bearing Antigen-Specific Immunoglobulin G▿ [O] . Sanjo, Hideki, Hikida, Masaki, Aiba, Yuichi, 2006

机译：胞外信号调节蛋白激酶2是B细胞有效产生带有抗原特异性免疫球蛋白G▿的B细胞所必需的

Extracellular Signal-Regulated Protein Kinase 2 Is Required for Efficient Generation of B Cells Bearing Antigen-Specific Immunoglobulin G

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