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首页> 外文期刊>Molecular and Cellular Biology >Mitochondrial Ribosomal Protein L41 Suppresses Cell Growth in Association with p53 and p27Kip1
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Mitochondrial Ribosomal Protein L41 Suppresses Cell Growth in Association with p53 and p27Kip1

机译：线粒体核糖体蛋白L41抑制与p53和p27Kip1相关的细胞生长

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The p53 protein arrests the cell cycle at the G1 phase when stabilized by the interaction between ribosomal proteins and HDM2 under growth-inhibitory conditions. Meanwhile, p53, when translocated to the mitochondria in response to cell death signals, induces apoptosis via transcription-independent mechanisms. In this report, we demonstrate that the mitochondrial ribosomal protein L41 (MRPL41) enhances p53 stability and contributes to p53-induced apoptosis in response to growth-inhibitory conditions such as actinomycin D treatment and serum starvation. An analysis of MRPL41 expression in paired normal and tumor tissues revealed lower expression in tumor tissue. Ectopic MRPL41 expression resulted in inhibition of the growth of cancer cells in tissue culture and tumor growth in nude mice. We discovered that MRPL41 protein is localized in the mitochondria, stabilizes the p53 protein, and enhances its translocation to the mitochondria, thereby inducing apoptosis. Interestingly, in the absence of p53, MRPL41 stabilizes the p27Kip1 protein and arrests the cell cycle at the G1 phase. These results suggest that MRPL41 plays an important role in p53-induced mitochondrion-dependent apoptosis and MRPL41 exerts a tumor-suppressive effect in association with p53 and p27 Kip1.
机译：在生长抑制条件下，通过核糖体蛋白和HDM2之间的相互作用稳定化后，p53蛋白将在G 1 阶段阻止细胞周期。同时，p53在响应细胞死亡信号转位至线粒体时，通过转录独立机制诱导凋亡。在此报告中，我们证明线粒体核糖体蛋白L41（MRPL41）增强p53的稳定性，并响应生长抑制条件（如放线菌素D处理和血清饥饿），促进p53诱导的细胞凋亡。配对的正常组织和肿瘤组织中的 MRPL41 表达分析表明，肿瘤组织中的表达较低。异位 MRPL41 的表达抑制了裸鼠体内组织培养中癌细胞的生长和肿瘤的生长。我们发现，MRPL41蛋白位于线粒体中，稳定p53蛋白，并增强其向线粒体的易位性，从而诱导细胞凋亡。有趣的是，在不存在p53的情况下，MRPL41可以稳定p27 Kip1 蛋白并使细胞周期停留在G 1 期。这些结果表明，MRPL41在p53诱导的线粒体依赖性细胞凋亡中起重要作用，而MRPL41与p53和p27 Kip1 相关联地发挥肿瘤抑制作用。

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