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首页> 外文期刊>Molecular and Cellular Biology >Interaction of SOS2 with Nucleoside Diphosphate Kinase 2 and Catalases Reveals a Point of Connection between Salt Stress and H2O2 Signaling in Arabidopsis thaliana
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Interaction of SOS2 with Nucleoside Diphosphate Kinase 2 and Catalases Reveals a Point of Connection between Salt Stress and H2O2 Signaling in Arabidopsis thaliana

机译：SOS2与核苷二磷酸激酶2和过氧化氢酶的相互作用揭示了拟南芥中盐胁迫和H2O2信号之间的联系点。

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摘要

SOS2, a class 3 sucrose-nonfermenting 1-related kinase, has emerged as an important mediator of salt stress response and stress signaling through its interactions with proteins involved in membrane transport and in regulation of stress responses. We have identified additional SOS2-interacting proteins that suggest a connection between SOS2 and reactive oxygen signaling. SOS2 was found to interact with the H2O2 signaling protein nucleoside diphosphate kinase 2 (NDPK2) and to inhibit its autophosphorylation activity. A sos2-2 ndpk2 double mutant was more salt sensitive than a sos2-2 single mutant, suggesting that NDPK2 and H2O2 are involved in salt resistance. However, the double mutant did not hyperaccumulate H2O2 in response to salt stress, suggesting that it is altered signaling rather than H2O2 toxicity alone that is responsible for the increased salt sensitivity of the sos2-2 ndpk2 double mutant. SOS2 was also found to interact with catalase 2 (CAT2) and CAT3, further connecting SOS2 to H2O2 metabolism and signaling. The interaction of SOS2 with both NDPK2 and CATs reveals a point of cross talk between salt stress response and other signaling factors including H2O2.
机译：SOS2是3类不参与蔗糖发酵的1相关激酶，通过与膜运输和调控应激反应的蛋白质相互作用，已成为盐胁迫响应和应激信号传递的重要介体。我们已经确定了其他SOS2相互作用蛋白，它们提示SOS2和活性氧信号之间存在联系。 SOS2被发现与H 2 O 2 信号蛋白核苷二磷酸激酶2（NDPK2）相互作用，并抑制其自磷酸化活性。 sos2 - 2 ndpk2 双突变体比 sos2 - 2 单突变体对盐更敏感，这表明NDPK2和H 2 O 2 与耐盐性有关。然而，双突变体并没有在盐胁迫下过度积累H 2 O 2 ，表明它是信号传导的改变而不是H 2 O单独的 2 毒性导致 sos2 - 2 ndpk2 双突变体的盐敏感性增加。还发现SOS2与过氧化氢酶2（CAT2）和CAT3相互作用，进一步将SOS2连接到H 2 O 2 的代谢和信号传导。 SOS2与NDPK2和CAT的相互作用揭示了盐胁迫响应与其他信号传导因子（包括H 2 O 2 ）之间的串扰点。

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