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首页> 外文期刊>Molecular and Cellular Biology >How a Cytokine Is Chaperoned through the Secretory Pathway by Complexing with Its Own Receptor: Lessons from Interleukin-15 (IL-15)/IL-15 Receptor α
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How a Cytokine Is Chaperoned through the Secretory Pathway by Complexing with Its Own Receptor: Lessons from Interleukin-15 (IL-15)/IL-15 Receptor α

机译：细胞因子如何通过与自身受体复合而通过分泌途径进行伴侣控制：白介素15（IL-15）/ IL-15受体α的教训

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摘要

While it is well appreciated that receptors for secreted cytokines transmit ligand-induced signals, little is known about additional roles for cytokine receptor components in the control of ligand transport and secretion. Here, we show that interleukin-15 (IL-15) translocation into the endoplasmic reticulum occurs independently of the presence of IL-15 receptor α (IL-15Rα). Subsequently, however, IL-15 is transported through the Golgi apparatus only in association with IL-15Rα and then is secreted. This intracellular IL-15/IL-15Rα complex already is formed in the endoplasmic reticulum and, thus, enables the further trafficking of complexed IL-15 through the secretory pathway. Just transfecting IL-15Rα in cells, which transcribe but normally do not secrete IL-15, suffices to induce IL-15 secretion. Thus, we provide the first evidence of how a cytokine is chaperoned through the secretory pathway by complexing with its own high-affinity receptor and show that IL-15/IL-15Rα offers an excellent model system for the further exploration of this novel mechanism for the control of cytokine secretion.
机译：众所周知，分泌细胞因子的受体会传递配体诱导的信号，但对于细胞因子受体组分在控制配体转运和分泌中的其他作用知之甚少。在这里，我们显示白介素15（IL-15）易位到内质网的发生与IL-15受体α（IL-15Rα）的存在无关。然而，随后，IL-15仅与IL-15Rα缔合通过高尔基体运输，然后被分泌。该细胞内IL-15 /IL-15Rα复合物已经在内质网中形成，因此能够通过分泌途径进一步运输复合的IL-15。仅仅转染转录但通常不分泌IL-15的细胞中的IL-15Rα就足以诱导IL-15分泌。因此，我们提供了第一个证据证明细胞因子如何与其自身的高亲和力受体复合，从而通过分泌途径进行伴侣控制，并证明IL-15 /IL-15Rα为进一步探索这种新的机制提供了一个极好的模型系统。控制细胞因子的分泌。

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