Caspase-10-Mediated Heat Shock Protein 90β Cleavage Promotes UVB Irradiation-Induced Cell Apoptosis

Hehua Chen; Yan Xia; Dexing Fang; David Hawke; Zhimin Lu

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Caspase-10-Mediated Heat Shock Protein 90β Cleavage Promotes UVB Irradiation-Induced Cell Apoptosis

机译：Caspase-10-介导的热休克蛋白90β裂解促进UVB辐射诱导的细胞凋亡。

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Heat shock protein 90β (Hsp90β) is involved in many cellular functions. However, the posttranslational modification of Hsp90β, especially in response to apoptotic stimulation, is not well understood. In this study, we found that Hsp90β was cleaved by activated caspase-10 under UVB irradiation. Caspase-10 activation, in turn, depended on caspase-8, which cleaved caspase-10 directly. Autocrine secretion of FAS ligand and upregulated FAS expression induced by UVB irradiation contributed to activation of caspase-10, which cleaved Hsp90β at D278, P293, and D294. The downregulation of Hsp90β mediated by caspase-8-dependent caspase-10 activation promoted UVB-induced cell apoptosis.

机译：热激蛋白90β（Hsp90β）参与许多细胞功能。但是，Hsp90β的翻译后修饰，尤其是对凋亡刺激的响应，尚不十分清楚。在这项研究中，我们发现Hsp90β在UVB照射下被活化的caspase-10裂解。反过来，caspase-10激活取决于caspase-8，后者直接裂解caspase-10。 FAS配体的自分泌分泌和UVB辐射诱导的FAS表达上调有助于caspase-10的活化，该酶在D278，P293和D294处切割Hsp90β。 caspase-8依赖性caspase-10激活介导的Hsp90β的下调促进了UVB诱导的细胞凋亡。

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《Molecular and Cellular Biology》 |2009年第13期|共8页
作者
Hehua Chen; Yan Xia; Dexing Fang; David Hawke; Zhimin Lu;
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中图分类细胞生物学;
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1. Caspase-10-mediated heat shock protein 90 beta cleavage promotes UVB irradiation-induced cell apoptosis. [J] . Chen H, Xia Y, Fang D, Postharvest Biology and Technology . 2009,第13期

机译：Caspase-10-介导的热休克蛋白90β切割促进UVB辐射诱导的细胞凋亡。
2. Caspase-10-Mediated Heat Shock Protein 90β Cleavage Promotes UVB Irradiation-Induced Cell Apoptosis [J] . Hehua Chen, Yan Xia, Dexing Fang, Molecular and Cellular Biology . 2009,第13期

机译：Caspase-10-介导的热休克蛋白90β裂解促进UVB辐射诱导的细胞凋亡。
3. UVB irradiation-induced changes in the 27-kd heat shock protein (HSP27) in human corneal epithelial cells. [J] . Shi B, Han B, Schwab IR, Cornea . 2006,第8期

机译：UVB辐射诱导人角膜上皮细胞中27 kd热激蛋白（HSP27）的变化。
4. Decreased levels of heat shock protein 70 and 90 in gut epithelial cells after exposure to plant lectins [C] . J. Koninkx, H. Ovelgonne, A. Pusztai, International Workshop on Antinutritional Factors in Legume Seeds and Rapeseed . 2004

机译：在暴露于植物凝集素后，肠道上皮细胞中的热休克蛋白70和90水平降低
5. Inhibition of heat-induced apoptosis in human tumor cells by heat shock protein 70 occurs upstream of mitochondrial membrane permeabilization through suppression ofc-Jun N-terminal kinase activity. [D] . Lachapelle, Guillaume. 2008

机译：通过抑制c-Jun N端激酶活性，热激蛋白70抑制人肿瘤细胞中的热诱导细胞凋亡发生在线粒体膜通透性的上游。
6. Caspase-10-Mediated Heat Shock Protein 90β Cleavage Promotes UVB Irradiation-Induced Cell Apoptosis [O] . Hehua Chen, Yan Xia, Dexing Fang, 2009

机译：Caspase-10-介导的热休克蛋白90β切割促进UVB辐射诱导的细胞凋亡。
7. Caspase-10-Mediated Heat Shock Protein 90β Cleavage Promotes UVB Irradiation-Induced Cell Apoptosis▿ [O] . Chen, Hehua, Xia, Yan, Fang, Dexing, 2009

机译：Caspase-10-介导的热休克蛋白90β裂解可促进UVB辐射诱导的细胞凋亡▿

Caspase-10-Mediated Heat Shock Protein 90β Cleavage Promotes UVB Irradiation-Induced Cell Apoptosis

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