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APRIL-Deficient Mice Have Normal Immune System Development

机译：APRIL缺陷小鼠的免疫系统发育正常

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APRIL (a proliferation-inducing ligand) is a member of the tumor necrosis factor (TNF) superfamily. APRIL mRNA shows high levels of expression in tumors of different origin and a low level of expression in normal cells. APRIL shares two TNF receptor family members, TACI and BCMA, with another TNF homolog, BLyS/BAFF. BLyS is involved in regulation of B-cell activation and survival and also binds to a third receptor, BR3/BAFF-R, which is not shared with APRIL. Recombinant APRIL and BLyS induce accumulation of B cells in mice, while BLyS deficiency results in severe B-cell dysfunction. To investigate the physiological role of APRIL, we generated mice that are deficient in its encoding gene. APRIL?/? mice were viable and fertile and lacked any gross abnormality. Detailed histological analysis did not reveal any defects in major tissues and organs, including the primary and secondary immune organs. T- and B-cell development and in vitro function were normal as well, as were T-cell-dependent and -independent in vivo humoral responses to antigenic challenge. These data indicate that APRIL is dispensable in the mouse for proper development. Thus, BLyS may be capable of fulfilling APRIL's main functions.
机译：APRIL（一种诱导增殖的配体）是肿瘤坏死因子（TNF）超家族的成员。 APRIL mRNA在不同来源的肿瘤中高表达，而在正常细胞中低表达。 APRIL有两个TNF受体家族成员TACI和BCMA，还有另一个TNF同源物BLyS / BAFF。 BLyS参与B细胞活化和存活的调节，并与第三种受体BR3 / BAFF-R结合，而后者与APRIL不共有。重组APRIL和BLyS诱导小鼠B细胞蓄积，而BLyS缺乏会导致严重的B细胞功能障碍。为了研究APRIL的生理作用，我们产生了缺乏其编码基因的小鼠。 APRIL ？/？ 小鼠是活的，可育的，并且没有任何明显的异常。详细的组织学分析未发现主要组织和器官（包括主要和次要免疫器官）有任何缺陷。 T细胞和B细胞发育以及体外功能也正常，体内对抗原激发的T细胞依赖性和非依赖性T细胞应答也是如此。这些数据表明，APRIL在小鼠中可用于正常发育。因此，BLyS可能能够履行APRIL的主要功能。

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