Severe Adenine Starvation Activates Ty1 Transcription and Retrotransposition in Saccharomyces cerevisiae

Anne-Laure Todeschini; Antonin Morillon; Mathias Springer; Pascale Lesage

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Severe Adenine Starvation Activates Ty1 Transcription and Retrotransposition in Saccharomyces cerevisiae

机译：严重的腺嘌呤饥饿激活酿酒酵母中的Ty1转录和逆转座。

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Ty1 retrotransposons of the yeast Saccharomyces cerevisiae are activated by different kinds of stress. Here we show that Ty1 transcription is stimulated under severe adenine starvation conditions. The Bas1 transcriptional activator, responsible for the induction of genes of the de novo AMP biosynthesis pathway (ADE) in the absence of adenine, is not involved in this response. Activation occurs mainly on Ty1 elements, whose expression is normally repressed by chromatin and is suppressed in a hta1-htb1Δ mutant that alters chromatin structure. Activation is also abolished in a snf2Δ mutant. Several regions of the Ty1 promoter are necessary to achieve full activation, suggesting that full integrity of the promoter sequences might be important for activation. Together, these observations are consistent with a model in which the activation mechanism involves chromatin remodeling at Ty1 promoters. The consequence of Ty1 transcriptional activation in response to adenine starvation is an increase in Ty1 cDNA levels and a relief of Ty1 dormancy. The retrotransposition of four native Ty1 elements increases in proportion to their increase in transcription. Implications for the regulation of Ty1 mobility by changes in Ty1 mRNA levels are discussed.

机译：酵母 Saccharomyces cerevisiae 的Ty1逆转座子受到不同压力的激活。在这里，我们显示在严重的腺嘌呤饥饿条件下，Ty1转录受到刺激。在缺少腺嘌呤的情况下负责诱导从头AMP生物合成途径的基因（ ADE ）的Bas1转录激活因子不参与此反应。激活主要发生在Ty1元件上，其表达通常被染色质抑制，并在改变染色质结构的hta1-htb1Δ突变体中被抑制。 snf2Δ突变体中的激活也被取消。 Ty1启动子的几个区域是实现完全激活所必需的，这表明启动子序列的完全完整性可能对激活很重要。总之，这些观察结果与其中激活机制涉及Ty1启动子上的染色质重塑的模型一致。 Ty1转录响应腺嘌呤饥饿激活的结果是Ty1 cDNA水平的增加和Ty1休眠的缓解。四个天然Ty1元件的逆转座与它们的转录增加成比例地增加。讨论通过改变Ty1 mRNA水平来调节Ty1移动性的含义。 展开▼

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《Molecular and Cellular Biology》 |2005年第17期|共14页

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Anne-Laure Todeschini; Antonin Morillon; Mathias Springer; Pascale Lesage;
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中图分类细胞生物学;

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1. A rare tRNA-Arg(CCU) that regulates Ty1 element ribosomal frameshifting is essential for Ty1 retrotransposition in Saccharomyces cerevisiae. [J] . B Faiola, D J Garfinkel, D P Moore, Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation . 1993,第2期

机译：罕见的调节Ty1元素核糖体移码的tRNA-Arg（CCU）对酿酒酵母中Ty1逆转座至关重要。

2. Activation of the Kss1 Invasive-Filamentous Growth Pathway Induces Ty1 Transcription and Retrotransposition inSaccharomyces cerevisiae [J] . Antonin Morillon, Mathias Springer, Pascale Lesage Molecular and Cellular Biology . 2000,第15期

机译：Kss1丝状生长途径的激活诱导酿酒酵母中的Ty1转录和逆转座。

3. The role of reactive oxygen species in the induction of Ty1 retrotransposition in Saccharomyces cerevisiae [J] . Stoycheva Teodora, Pesheva Margarita, Venkov Pencho Yeast . 2010,第5期

机译：活性氧在酿酒酵母Ty1逆转座中的作用

4. Controllability Analysis of Transcriptional Regulatory Networks for Saccharomyces Cerevisiae [C] . Suling Liu, Qiong Xu, Aimin Chen, Annual Conference of the IEEE Industrial Electronics Society . 2018

机译：酿酒酵母转录调控网络的可控性分析

5. Upstream activation sequence function in Saccharomyces cerevisiae: The potential for long distance transcriptional activation and the role of Sin4. [D] . Dobi, Krista Carol. 2007

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6. Severe Adenine Starvation Activates Ty1 Transcription and Retrotransposition in Saccharomyces cerevisiae [O] . Anne-Laure Todeschini, Antonin Morillon, Mathias Springer, 2002

机译：严重的腺嘌呤饥饿激活酿酒酵母中的Ty1转录和逆转座。

7. Severe Adenine Starvation Activates Ty1 Transcription and Retrotransposition in Saccharomyces cerevisiae [O] . Todeschini, Anne-Laure, Morillon, Antonin, Springer, Mathias, 2005

机译：严重的腺嘌呤饥饿激活酿酒酵母中的Ty1转录和逆转座。

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Severe Adenine Starvation Activates Ty1 Transcription and Retrotransposition in Saccharomyces cerevisiae

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