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首页> 外文期刊>Molecular and Cellular Biology >Transcription Factor Gene AP-2γ Essential for Early Murine Development
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Transcription Factor Gene AP-2γ Essential for Early Murine Development

机译：转录因子基因AP-2γ对早期小鼠发育至关重要。

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Transcription factor gene AP-2γ belongs to a family of four closely related genes. AP-2γ had been implicated in multiple functions during proliferation and differentiation based on its expression pattern in trophoblast, neural crest, and ectoderm cells in murine embryos. In order to address the question of the role of AP-2γ during mammalian development, we generated mice harboring a disrupted AP-2γ allele. AP-2γ heterozygous mice are viable and display reduced body sizes at birth but are fertile. Mice deficient for AP-2γ, however, are growth retarded and die at days 7 to 9 of embryonic development. Immunohistochemical analysis revealed that the trophectodermal cells that are found to express AP-2γ fail to proliferate, leading to failure of labyrinth layer formation. As a consequence, the developing embryo suffers from malnutrition and dies. Analysis of embryo cultures suggests that AP-2γ is also implicated in the regulation of the adenosine deaminase (ADA) gene, a gene involved in purine metabolism found expressed at the maternal-fetal interface. Therefore, AP-2γ seems to be required in early embryonic development because it regulates the genetic programs controlling proliferation and differentiation of extraembryonic trophectodermal cells.
机译：转录因子基因 AP-2 γ属于四个密切相关的基因家族。根据 AP-2 γ在鼠胚胎滋养层，神经rest和外胚层细胞中的表达模式，其在增殖和分化过程中具有多种功能。为了解决 AP-2 γ在哺乳动物发育过程中的作用的问题，我们生成了带有 AP-2 γ等位基因被破坏的小鼠。 AP-2 γ杂合小鼠具有生存能力，出生时体形减小，但可育。然而，缺乏 AP-2 γ的小鼠生长迟缓，并在胚胎发育的第7至9天死亡。免疫组织化学分析表明，发现表达 AP-2 γ的滋养皮细胞不能增殖，导致迷宫层形成失败。结果，发育中的胚胎营养不良并死亡。对胚胎培养物的分析表明， AP-2 γ也与腺苷脱氨酶（ADA）基因的调控有关，该基因与嘌呤代谢有关，在母胎界面表达。因此， AP-2 γ似乎在早期胚胎发育中是必需的，因为它调节着控制胚外滋养外胚层细胞增殖和分化的遗传程序。

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