Nonautonomous Apoptosis Is Triggered by Local Cell Cycle Progression during Epithelial Replacement in Drosophila

Yu-ichiro Nakajima; Erina Kuranaga; Kaoru Sugimura; Atsushi Miyawaki; Masayuki Miura

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Nonautonomous Apoptosis Is Triggered by Local Cell Cycle Progression during Epithelial Replacement in Drosophila

机译：果蝇上皮置换过程中的局部细胞周期进程触发非自主凋亡。

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Tissue remodeling involves collective cell movement, and cell proliferation and apoptosis are observed in both development and disease. Apoptosis and proliferation are considered to be closely correlated, but little is known about their coordinated regulation in physiological tissue remodeling in vivo. The replacement of larval abdominal epidermis with adult epithelium in Drosophila pupae is a simple model of tissue remodeling. During this process, larval epidermal cells (LECs) undergo apoptosis and are replaced by histoblasts, which are adult precursor cells. By analyzing caspase activation at the single-cell level in living pupae, we found that caspase activation in LECs is induced at the LEC/histoblast boundary, which expands as the LECs die. Manipulating histoblast proliferation at the LEC/histoblast boundary, either genetically or by UV illumination, indicated that local interactions with proliferating histoblasts triggered caspase activation in the boundary LECs. Finally, by monitoring the spatiotemporal dynamics of the S/G₂/M phase in histoblasts in vivo, we found that the transition from S/G₂ phases is necessary to induce nonautonomous LEC apoptosis at the LEC/histoblast boundary. The replacement boundary, formed as caspase activation is regulated locally by cell-cell communication, may drive the dynamic orchestration of cell replacement during tissue remodeling.

机译：组织重塑涉及集体细胞运动，并且在发育和疾病中均观察到细胞增殖和凋亡。细胞凋亡和增殖被认为是密切相关的，但对它们在体内生理组织重塑中的协调调控知之甚少。果蝇p中成虫上皮代替幼虫腹部表皮是组织重塑的简单模型。在此过程中，幼虫表皮细胞（LEC）经历凋亡，并被成年成体前体细胞成纤维细胞所取代。通过分析活p中单细胞水平的caspase活化，我们发现LEC中的caspase活化是在LEC /成组织细胞边界诱导的，该边界随着LEC死亡而扩大。通过遗传学或通过紫外线照射在LEC /成纤维细胞边界处操纵成纤维细胞增殖，表明与增殖的成纤维细胞的局部相互作用触发了边界LEC中的半胱天冬酶激活。最后，通过监测体内成纤维细胞中S / G _{2 / M期的时空动态，我们发现S / G _{2 阶段是必要的，以诱导LEC /组织母细胞边界的非自主性LEC细胞凋亡。由半胱天冬酶激活而形成的置换边界是通过细胞间通讯来局部调节的，它可以驱动组织重塑过程中细胞置换的动态编排。}} 展开▼

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《Molecular and Cellular Biology》 |2011年第12期|共14页

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Yu-ichiro Nakajima; Erina Kuranaga; Kaoru Sugimura; Atsushi Miyawaki; Masayuki Miura;
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中图分类细胞生物学;

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2. Loss of Drosophila pseudouridine synthase triggers apoptosis-induced proliferation and promotes cell-nonautonomous EMT [J] . R Vicidomini, A Di Giovanni, A Petrizzo, Cell death & disease. . 2015,第3期

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3. Porcine epidemic diarrhea virus M protein blocks cell cycle progression at S-phase and its subcellular localization in the porcine intestinal epithelial cells [J] . Xu X. G., Zhang H. L., Zhang Q., Acta Virologica: International Journal . 2015,第3期

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5. The Protective Effects of Natural Antioxidants on Ionizing Radiation-Induced Apoptosis and Cell Cycle Arrest in Human Intestinal Epithelial Cells [D] . Alshihri, Abdulaziz. 2020

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6. Nonautonomous Apoptosis Is Triggered by Local Cell Cycle Progression during Epithelial Replacement in Drosophila [O] . Yu-ichiro Nakajima, Erina Kuranaga, Kaoru Sugimura, 2011

机译：非自主性细胞凋亡是由果蝇上皮置换过程中的局部细胞周期进程触发的。

7. Nonautonomous Apoptosis Is Triggered by Local Cell Cycle Progression during Epithelial Replacement in Drosophila ▿ † [O] . Nakajima, Yu-ichiro, Kuranaga, Erina, Sugimura, Kaoru, 2011

机译：果蝇上皮置换过程中局部细胞周期进程触发非自主性凋亡Ap†

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Nonautonomous Apoptosis Is Triggered by Local Cell Cycle Progression during Epithelial Replacement in Drosophila

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