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首页> 外文期刊>Molecules >Herbal Formula HT048 Attenuates Diet-Induced Obesity by Improving Hepatic Lipid Metabolism and Insulin Resistance in Obese Rats
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Herbal Formula HT048 Attenuates Diet-Induced Obesity by Improving Hepatic Lipid Metabolism and Insulin Resistance in Obese Rats

机译：草药配方HT048通过改善肥胖大鼠的肝脂质代谢和胰岛素抵抗来减轻饮食诱导的肥胖

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It is well established that obesity causes a variety of chronic diseases such as cardiovascular diseases and diabetes. Despite the diligent scientific efforts to find effective ways to lower the level of obesity, the size of obese population grows continuously around the world. Here we present the results that show feeding diet containing HT048, a mixture of the extracts of Crataegus pinnatifida leaves and Citrus unshiu peel, two of the well-known traditional herbal medicines in Eastern Asia, decreases obesity in rats. We fed rats with five different diets for 10 weeks: chow diet (STD), high-fat diet (HFD), high-fat diet with 0.04% orlistat, a drug to treat obesity (HFD + Orlistat), high-fat diet with 0.2% HT048 ( w / w ; HFD + 0.2% HT048), and high-fat diet with 0.6% HT048 ( w / w ; HFD + 0.6% HT048). It was found that both body and total white adipose tissue weight of HT048 groups significantly decreased compared to those of the HFD group. Moreover, HT048 decreased serum insulin levels in HFD-fed obese rats. At the molecular level, HT048 supplementation downregulated genes involved in lipogenesis, gluconeogenesis, and adipogenesis, while the expression level of β-oxidation genes was increased. Supplementation-drug interactions are not likely as HFD and HT048-containing diet did not significantly induce genes encoding CYPs. Collectively, this study suggests that HT048 taken as dietary supplement helps to decrease obesity and insulin resistance in HFD-fed obese rats.
机译：众所周知，肥胖会引起多种慢性疾病，例如心血管疾病和糖尿病。尽管科学地努力寻找降低肥胖水平的有效方法，但肥胖人口的规模在世界范围内仍在不断增长。在这里，我们提供的结果显示，喂食含有HT048的饲料饮食，该混合物是藏于东部亚洲的两种传统传统草药-景天树叶子和柑桔皮的提取物的混合物，可降低大鼠的肥胖症。我们为大鼠提供了五种不同的饮食，为期10周：食物（STD），高脂饮食（HFD），含0.04％奥利司他的高脂饮食，治疗肥胖症的药物（HFD + Orlistat）， 0.2％HT048（w / w; HFD + 0.2％HT048），高脂饮食含0.6％HT048（w / w; HFD + 0.6％HT048）。发现与HFD组相比，HT048组的体重和白色脂肪组织总重量均显着降低。此外，HT048降低了由HFD喂养的肥胖大鼠的血清胰岛素水平。在分子水平上，HT048补充下调了与脂肪生成，糖异生和脂肪形成有关的基因，而β-氧化基因的表达水平增加了。补充药物的相互作用不太可能，因为含HFD和HT048的饮食不会显着诱导编码CYP的基因。总体而言，这项研究表明，HT048作为膳食补充剂有助于降低由HFD喂养的肥胖大鼠的肥胖和胰岛素抵抗。

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