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首页> 外文期刊>Molecules >Five Unprecedented Secondary Metabolites from the Spider Parasitic Fungus Akanthomyces novoguineensis
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Five Unprecedented Secondary Metabolites from the Spider Parasitic Fungus Akanthomyces novoguineensis

机译：来自蜘蛛寄生真菌Akanthomyces novoguineensis的五个前所未有的次级代谢产物

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摘要

Five new compounds including the glycosylated β-naphthol (1, akanthol), a glycosylated pyrazine (2, akanthozine), and three amide derivatives including a hydroxamic acid derivative (3–5) were isolated from the spider-associated fungus Akanthomyces novoguineensis (Cordycipitaceae, Ascomycota). Their structures were elucidated by using high resolution mass spectrometry (HRMS) and NMR spectroscopy. In this study, the antimicrobial, cytotoxic, anti-biofilm, and nematicidal activities of the new compounds were evaluated. The distribution pattern of secondary metabolites in the species was also revealed in which more isolates of A. novoguineensis were encountered and their secondary metabolite profiles were examined using analytical HPLC with diode array and mass spectrometric detection (HPLC-DAD/MS). Remarkably, all isolated compounds are specifically produced by A. novoguineensis. View Full-Text
机译：从与蜘蛛相关的真菌Akanthomyces novoguineensis（Cordycipitaceae）中分离了五个新化合物，包括糖基化的β-萘酚（1，akanthol），糖基化的吡嗪（2，akanthozine）和三种酰胺衍生物，包括异羟肟酸衍生物（3-5）。 ，子囊）。通过使用高分辨率质谱（HRMS）和NMR光谱阐明了它们的结构。在这项研究中，评估了新化合物的抗微生物，细胞毒性，抗生物膜和杀线虫活性。还揭示了该物种中次生代谢产物的分布模式，其中遇到了更多的新农杆菌菌株，并使用带有二极管阵列的分析型HPLC和质谱检测（HPLC-DAD / MS）检查了它们的次生代谢产物谱。值得注意的是，所有分离出的化合物都是由新奇农杆菌专门产生的。查看全文

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