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首页> 外文期刊>Kidney international. >Renotropic growth factor found in cancer patient sera after removal of cancer-bearing kidney
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Renotropic growth factor found in cancer patient sera after removal of cancer-bearing kidney

机译：去除患癌肾脏后在癌症患者血清中发现的促肾上腺生长因子

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摘要

It is a well established fact that the removal or injury of one kidney results in renal growth of the other kidney [1]. This compensatory renal growth is controlled by a humoral serum factor(s) which is induced by reduction of renal functions [2–5]. Therefore, this humoral factor, so-called renotropin or renotropic growth factor, should also stimulate growth of the healthy area of the physically injured or disease-bearing kidney in addition to the other kidney.In experimental animals the extent of renal growth is known to be related directly to the portion of the kidney mass (partially or subtotally) removed [6]. Thus, the amount of renotropic growth factor produced should be proportional to the amount of renal function lost. In cancer-bearing kidneys, the enlargement and infiltration of cancer in kidneys theoretically should produce the renotropic growth factor and stimulate healthy tissue to grow. When a cancer-bearing kidney is removed, the lost proportion of renal function should be responsible for the amount of renotropic growth factor produced.In this communication we demonstrate the renotropic growth factor in renal cancer patient sera after uninephrectomy and an assay procedure for renotropic growth factor using noncancerous cells from a cancer-bearing kidney.
机译：一个公认的事实是，一个肾脏的切除或损伤会导致另一个肾脏的肾脏生长[1]。这种代偿性肾生长受体液血清因子的控制，后者是由肾功能降低引起的[2-5]。因此，这种体液因子，即所谓的肾上腺素或促肾上腺生长因子，除了刺激其他肾脏外，还应该刺激身体受伤或患有疾病的肾脏的健康区域的生长。在实验动物中，已知肾脏的生长程度与摘除的肾脏部分（部分或小结）直接相关[6]。因此，产生的促肾上腺生长因子的量应与肾功能丧失的量成比例。理论上，在患有癌症的肾脏中，肾脏中癌症的扩散和浸润应产生促肾上腺生长因子并刺激健康组织的生长。当切除了一个患有癌症的肾脏时，肾功能的丧失比例应该是所产生的促肾上腺生长因子的量的原因。在本通讯中，我们证明了进行肾切除后肾癌患者血清中的促肾上腺生长因子和促肾上腺生长的测定方法使用来自患有癌症的肾脏的非癌细胞来抑制肿瘤的发生。

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