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Optimization of Ultrasonic-Assisted Extraction and Purification of Rhein from Cassia fistula Pod Pulp

机译：超声波辅助提取纯化决明子荚果浆中大黄酸的工艺研究

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摘要

Rhein is used as an active ingredient in laxatives in medicinal herbal products and is a chemical marker for quality control purposes. Thus, a simple and effective method for the optimized extraction of a high amount of rhein from the fruit pulp of Cassia fistula was investigated using ultrasonic-assisted extraction (UAE). The response surface methodology was applied to find the most suitable parameters for optimizing the extraction process and to study the factors’ relationships with each other. The best conditions for ultrasonic extraction were the application of 1:40 g/mL solid-to-liquid ratio and 10% EtOH–H2O as a solvent at 75 °C for 40 min. This method was compared to a conventional decoction in two variations. In these experiments, it was confirmed that the UAE was more favorable than the decoction methods. The resulting crude extract was further purified by liquid–liquid extraction with a basic pH adjustment, followed by recrystallization. High-purity rhein was obtained by using chromatographic techniques and nuclear magnetic resonance spectroscopy. Therefore, this study suggests that UAE is an efficient alternative method for the extraction of rhein from C. fistula pod pulp. The resulting optimized conditions can be applied as a useful tool for the large-scale industrial production of a rhein-rich plant extract.
机译：大黄酸在药用草药产品中用作泻药的活性成分，并且是用于质量控制的化学标记。因此，研究了一种简单有效的方法，利用超声波辅助提取（UAE）从决明子的果肉中优化提取大量的大黄酸。应用响应面方法来找到最适合的参数，以优化提取过程并研究各因素之间的关系。超声提取的最佳条件是在75°C的条件下，以1:40 g / mL的固液比和10％的EtOH-H2O作为溶剂进行40分钟的萃取。将该方法与常规汤剂进行了两种比较。在这些实验中，证实了阿联酋比水煎法更有利。将得到的粗提物通过液-液萃取进一步纯化，并调节碱性pH值，然后重结晶。通过使用色谱技术和核磁共振光谱法获得了高纯度的大黄酸。因此，这项研究表明，阿联酋是从瘘管荚果浆中提取大黄酸的一种有效的替代方法。所得的优化条件可以用作大规模工业生产富含大黄酸的植物提取物的有用工具。

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