Time-evolution and reversibility of strontium-induced osteomalacia in chronic renal failure rats

LINE OSTE; AN R BERVOETS; GEERT J BEHETS; GEERT DAMS; RITA L MARIJNISSEN; HILDE GERYL; LUDWIG V LAMBERTS; STEVEN C VERBERCKMOES; VIVIANE O VAN HOOF; MARC E DE BROE; PATRICK C DHAESE

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Time-evolution and reversibility of strontium-induced osteomalacia in chronic renal failure rats

机译：锶诱发慢性肾功能衰竭大鼠骨软化的时间演变和可逆性

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Time-evolution and reversibility of strontium-induced osteomalacia in chronic renal failure rats.BackgroundPatients with impaired renal function can accumulate strontium in the bone, which has been associated with the development of osteomalacia. A causal role for strontium in the development of the disease was presented in chronic renal failure (CRF) rats. Strontium-ranelate has been put forward as a therapeutic agent in the treatment of osteoporosis. Since the target population for strontium treatment consists mainly in postmenopausal osteoporotic women, who may have a reduced renal function, the risk for osteomalacia should be considered.

机译：锶引起的慢性肾功能衰竭大鼠骨软化症的时间演变和可逆性。肾功能受损的患者可以在骨骼中积累锶，这与骨软化症的发展有关。在慢性肾功能衰竭（CRF）大鼠中，锶在疾病发展中起因果作用。有人提出了雷奈酸锶作为骨质疏松症的治疗剂。由于锶治疗的目标人群主要是绝经后的骨质疏松妇女，他们的肾功能可能降低，因此应考虑发生骨软化症的风险。

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《Kidney international.》 |2005年第3期|共11页
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LINE OSTE; AN R BERVOETS; GEERT J BEHETS; GEERT DAMS; RITA L MARIJNISSEN; HILDE GERYL; LUDWIG V LAMBERTS; STEVEN C VERBERCKMOES; VIVIANE O VAN HOOF; MARC E DE BROE; PATRICK C DHAESE;
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中图分类泌尿科学（泌尿生殖系疾病）;
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1. Strontium causes osteomalacia in chronic renal failure rats [J] . Iris Schrooten, Walter Cabrera, William G Goodman, Kidney international. . 1998,第2期

机译：锶导致慢性肾功能衰竭大鼠骨软化症
2. The Intestinal Absorption of Phosphorus. Its Relation to Calcium Absorption and to Treatment with Vitamin D in Osteomalacia, Parathyroid Dysfunction and Chronic Renal Failure [J] . T. C. B. Stamp Clinical Science . 1972,第4期

机译：肠道对磷的吸收。其与骨吸收，甲状旁腺功能减退和慢性肾功能衰竭的钙吸收及维生素D治疗的关系
3. Reversible hypocalcemic heart failure with T wave alternans and increased QTc dispersion in a patient with chronic renal failure after parathyroidectomy. [J] . Iwazu Y, Muto S, Ikeuchi S, Clinical nephrology . 2006,第1期

机译：甲状旁腺切除术后慢性肾功能衰竭的可逆性低钙血症性心力衰竭伴T波交替蛋白和QTc离散度增加。
4. Disability Prevention of Chronic Renal Failure (CRF): Beneficial Effects of Combination of Chronic Exercise, and Anti-hypertensive Drugs on Skeletal Capillaries, Exercise Endurance, and Renal Function in Rats with CRF [C] . A. Ishida, M. Kanazawa, H. Lu, International Society of Physical and Rehabilitation Medicine . 2007

机译：残疾预防慢性肾功能衰竭（CRF）：慢性运动结合，抗高血压药物对CRF大鼠骨骼毛细血管，锻炼耐久性和肾功能的益处合
5. THE SIGNIFICANCE OF PARATHYROID HORMONE IN THE PATHOGENESIS OF THE ANEMIA OF CHRONIC RENAL FAILURE [D] . PETRITES-MURPHY, MARIE BERNADETTE. 1986

机译：副甲状腺激素在慢性肾功能衰竭贫血的发病中的意义
6. Osteomalacia and chronic renal failure. [O] . J A Kanis 1981

机译：骨软化症和慢性肾功能衰竭。
7. Time-evolution and reversibility of strontium-induced osteomalacia in chronic renal failure rats [O] . Oste, L., Bervoets, A.J., Behets, G.J., 2005

机译：锶诱发慢性肾衰竭大鼠骨软化的时间演变和可逆性

Time-evolution and reversibility of strontium-induced osteomalacia in chronic renal failure rats

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