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Metabolic syndrome and chronic kidney disease in Okinawa, Japan

机译：日本冲绳县的代谢综合症和慢性肾脏疾病

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We assessed the prevalence of chronic kidney disease (CKD) in a hospital-based screening program in Okinawa, Japan. The significance of metabolic syndrome as a determinant of CKD was examined using multivariate logistic regression analysis. A total of 6980 participants, aged 30–79 years, participated in a screening program in Tomishiro Chuo Hospital. Metabolic syndrome was defined according to the criteria of the Adult Treatment Panel III (ATP III). Data were also analyzed according to the modified criteria of the National Cholesterol Education Program (NCEP) that defines abdominal obesity as a waist circumference of 85cm in men and 90cm in women. CKD was defined as dipstick proteinuria (1+) or a reduced glomerular filtration rate (GFR). GFR was estimated using the abbreviated Modification of Diet in Renal Disease (MDRD) formula. The prevalence of metabolic syndrome and CKD was 12.8 and 13.7%, respectively. Metabolic syndrome was a significant determinant of CKD (adjusted odds ratio (OR) 1.537 and 95% confidence interval (CI) 1.277–1.850, PP=0.0029) for those with four metabolic syndrome risk factors compared to those with no metabolic syndrome risk factors. Metabolic syndrome was a significant determinant for younger participants (P<0.0001), but not for older participants (60 years; OR 1.254, 95% CI 0.906–1.735, NS). The relationship between the number of metabolic syndrome risk factors and the prevalence of CKD was linear using the modified criteria. The results suggest that metabolic syndrome is a significant determinant of CKD in men under 60 years of age, in Okinawa, Japan.
机译：我们在日本冲绳的一家医院筛查计划中评估了慢性肾脏病（CKD）的患病率。使用多元逻辑回归分析检查了代谢综合征作为CKD决定因素的重要性。共有6980位年龄在30-79岁的参与者参加了富四郎中央医院的筛查计划。代谢综合征是根据成人治疗小组III（ATP III）的标准定义的。还根据国家胆固醇教育计划（NCEP）的修改标准对数据进行了分析，该标准将腹部肥胖定义为男性的腰围为85厘米，女性的腰围为90厘米。 CKD定义为试纸尿蛋白尿（1+）或肾小球滤过率降低（GFR）。使用肾病中饮食的缩写（MDRD）公式来估算GFR。代谢综合征和CKD的患病率分别为12.8和13.7％。与没有代谢综合征危险因素的人相比，具有四个代谢综合征危险因素的人，代谢综合征是CKD的重要决定因素（校正比值比（OR）1.537和95％置信区间（CI）1.277-1.850，PP = 0.0029） 。代谢综合征是年轻参与者（P <0.0001）的重要决定因素，但对于年长参与者（60岁; OR 1.254，95％CI 0.906-1.735，NS）不是决定因素。使用修改后的标准，代谢综合征危险因素数量与CKD患病率之间的关系呈线性关系。结果表明，在日本冲绳县，代谢综合征是60岁以下男性中CKD的重要决定因素。

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