Activation of the unfolded protein response in Pichia pastoris requires splicing of a HAC1 mRNA intron and retention of the C‐terminal tail of Hac1p

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Activation of the unfolded protein response in Pichia pastoris requires splicing of a HAC1 mRNA intron and retention of the C‐terminal tail of Hac1p

机译：巴斯德毕赤酵母中未折叠的蛋白应答的激活需要剪接HAC1 mRNA内含子并保留Hac1p的C末端尾巴

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Wehaveshownthattheunfoldedproteinresponse(UPR)inPichiapastorisrequiressplicingofanon‐conventionalintronintheHAC1umRNAincommonwithothereukaryotes.P.pastorisisafavouredyeastexpressionhostforsecretedproductionofheterologousproteinsandtheregulationoftheUPRinP.pastorismayholdthekeytoitseffectivefoldingandsecretionofproteins.WehavealsoshownthattheC‐terminalregionoftheHac1pfromP.pastorisisrequiredforfunctionality.AlthoughtheC‐terminalregionsofHac1pfrombothS.cerevisiaeandP.pastorisarerichinphenylalanineresidues,theP.pastorisHac1placksaC‐terminalserinethatisknowntobeimportantintheefficientfunctionalityofHac1pfromS.cerevisiae...

机译：Wehaveshownthattheunfoldedproteinresponse（UPR）inPichiapastorisrequiressplicingofanon-conventionalintronintheHAC1umRNAincommonwithothereukaryotes.P.pastorisisafavouredyeastexpressionhostforsecretedproductionofheterologousproteinsandtheregulationoftheUPRinP.pastorismayholdthekeytoitseffectivefoldingandsecretionofproteins.WehavealsoshownthattheC-terminalregionoftheHac1pfromP.pastorisisrequiredforfunctionality.AlthoughtheC-terminalregionsofHac1pfrombothS.cerevisiaeandP.pastorisarerichinphenylalanineresidues，theP.pastorisHac1placksaC-terminalserinethatisknowntobeimportantintheefficientfunctionalityofHac1pfromS.cerevisiae ...

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《FEBS Letters》 |2011年第7期|共5页
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1. Activation of the unfolded protein response in Pichia pastoris requires splicing of a HAC1 mRNA intron and retention of the C-terminal tail of Hac1p. [J] . Whyteside G, Nor RM, Alcocer MJ, FEBS letters. . 2011,第7期

机译：巴斯德毕赤酵母中未折叠蛋白应答的激活需要剪接HAC1 mRNA内含子并保留Hac1p的C末端尾巴。
2. mRNA splicing-mediated C-terminal replacement of transcription factor Hac1p is required for efficient activation of the unfolded protein response [J] . Kazutoshi Mori, Naoki Ogawa, Tetsushi Kawahara Proceedings of the National Academy of Sciences of the United States of America . 2000,第9期

机译：mRNA剪接介导的转录因子Hac1p的C端置换是有效激活未折叠蛋白应答的必需条件
3. Regulating unfolded protein response activator HAC1p for production of thermostable raw-starch hydrolyzing alpha-amylase in Pichia pastoris [J] . Huang Mengmeng, Gao Yanyun, Zhou Xiangshan, Bioprocess and Biosystems Engineering . 2017,第3期

机译：调节未折叠的蛋白反应激活剂HAC1p在巴斯德毕赤酵母中生产热稳定的生淀粉水解α-淀粉酶
4. RNA Terminus Chemistry Potentiates Decay Events That Target HAC1 mRNA During the Unfolded Protein Response [D] . Cherry, Patrick. 2019

机译：RNA末端化学增强衰变在展开蛋白质反应期间靶向HAC1 mRNA的衰变事件
5. mRNA splicing-mediated C-terminal replacement of transcription factor Hac1p is required for efficient activation of the unfolded protein response [O] . Kazutoshi Mori, Naoki Ogawa, Tetsushi Kawahara, 2000

机译：mRNA剪接介导的转录因子Hac1p的C端置换是有效激活未折叠蛋白应答的必需条件
6. Activation of the unfolded protein response in Pichia pastoris requires splicing of a HAC1 mRNA intron and retention of the C-terminal tail of Hac1p [O] . Whyteside Graham, Nor Rohana Mat, Alcocer Marcos J.C., 2011

机译：巴斯德毕赤酵母中未折叠蛋白应答的激活需要剪接HAC1 mRNA内含子并保留Hac1p的C末端尾巴

Activation of the unfolded protein response in Pichia pastoris requires splicing of a HAC1 mRNA intron and retention of the C‐terminal tail of Hac1p

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