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首页> 外文期刊>RSC Advances >Nanoarchitectures by hierarchical self-assembly of ursolic acid: entrapment and release of fluorophores including anticancer drug doxorubicin
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Nanoarchitectures by hierarchical self-assembly of ursolic acid: entrapment and release of fluorophores including anticancer drug doxorubicin

机译：熊果酸分级自组装的纳米结构：包括抗癌药阿霉素在内的荧光团的捕获和释放

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摘要

Ursolic acid, a naturally occurring 6-6-6-6-6 monohydroxytriterpenic acid, is extractable from the leaves of Plumeria rubra. In continuation of our ongoing efforts on the studies of the self-assembly properties of naturally occurring triterpenoids, herein, we report our detailed investigation on the self-assembly of this ursane type triterpenic acid in different liquids. The molecule self-assembles in most organic as well as aqueous organic liquids yielding nano-architectures such as vesicles, tubes, fibers and flowers affording supramolecular gels in many of the liquids studied. Characterization of the self-assemblies has been carried out using atomic force microscopy, scanning electron microscopy, transmission electron microscopy, optical microscopy, dynamic light scattering, FTIR and X-ray diffraction studies. The self-assemblies have been utilized for the entrapment of fluorophores including an anticancer drug, doxorubicin. Release of the entrapped fluorophores including doxorubicin has been demonstrated at physiological pH as well as lower pH values.
机译：乌索酸是天然存在的6-6-6-6-6单羟基三萜酸，可从 Plumeria rubra 的叶子中提取。在继续研究天然存在的三萜类化合物的自组装性质的努力中，我们在此报告了我们对这种乌苏烷型三萜酸在不同液体中的自组装的详细研究。该分子可在大多数有机和水性有机液体中自组装，产生纳米结构，例如囊泡，管，纤维和花朵，从而在许多研究的液体中提供超分子凝胶。自组装的表征已经使用原子力显微镜，扫描电子显微镜，透射电子显微镜，光学显微镜，动态光散射，FTIR和X射线衍射研究进行了。自组装体已被用于包埋包括抗癌药阿霉素的荧光团。已经证明在生理pH以及较低的pH值下释放出包含阿霉素的包埋的荧光团。

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