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Peptide having eight amino acid sequences derived from cage and retaining anticancer activity and activity to promote anticancer drug sensitivity of anticancer drug-resistant cancer cells
Peptide having eight amino acid sequences derived from cage and retaining anticancer activity and activity to promote anticancer drug sensitivity of anticancer drug-resistant cancer cells
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机译：具有源自笼子的八个氨基酸序列并保持抗癌活性和提高抗癌药耐药性癌细胞的抗癌药敏感性的活性的肽
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摘要
A peptide having eight amino acid sequences derived from cancer-associated gene (CAGE) is described which retains anticancer activity and activity to promote anticancer drug sensitivity of anticancer drug resistant cancer cells. Specifically, a peptide which has an amino acid sequence of SEQ ID NO: 1 (AQTGTGKT) and thus binds to the CAGE protein is disclosed, which inhibits an inter-linkage between CAGE and GSK3β, thus exhibiting anticancer activity and activity to promote anticancer drug sensitivity of anticancer drug resistant cancer cells. A pharmaceutical composition is also disclosed containing the peptide with the amino acid sequence of SEQ ID NO: 1 (AQTGTGKT), for anticancer use or anticancer drug aiding.
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机译：描述了具有衍生自癌症相关基因（CAGE）的八个氨基酸序列的肽，其保留抗癌活性和促进对抗癌药耐药性癌细胞的抗癌药敏感性的活性。具体地，公开了具有氨基酸序列SEQ ID NO：1（AQTGTGKT）并因此与CAGE蛋白结合的肽，其抑制了CAGE和GSK3β之间的相互连接，因此表现出抗癌活性和促进抗癌药物的活性。抗癌药物耐药细胞的敏感性。还公开了药物组合物，其包含具有SEQ ID NO：1的氨基酸序列的肽（AQTGTGKT），用于抗癌用途或辅助抗癌药物。
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