Immobilized boronic acid for Suzuki–Miyaura coupling: application to the generation of pharmacologically relevant molecules

M. Martinez-Amezaga; C. M. L. Delpiccolo; E. G. Mata

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Immobilized boronic acid for Suzuki–Miyaura coupling: application to the generation of pharmacologically relevant molecules

机译：用于铃木-宫浦偶联的固定化硼酸：在药理学相关分子的产生中的应用

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An synthetic strategy for the generation of a variety of biaryl and related derivatives, based on Suzuki–Miyaura coupling using immobilized boronic acid, is described. The importance of the methodology was demonstrated by its further application to biologically interesting compounds such as 4-biaryl-β-lactams, descripted as cholesterol absorption inhibitors and anti-MRSA active agents, neoflavonoids, imidazoles, isoxazolines, among others.

机译：描述了基于使用固定化硼酸的Suzuki-Miyaura偶联生成多种联芳基和相关衍生物的合成策略。该方法的重要性已通过将其进一步应用于生物学上有意义的化合物（例如被描述为胆固醇吸收抑制剂和抗MRSA活性剂的4-联芳基-β-内酰胺，新类黄酮，咪唑，异恶唑啉等）来证明。

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《RSC Advances》 |2017年第56期|共10页
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M. Martinez-Amezaga; C. M. L. Delpiccolo; E. G. Mata;
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1. Neoglycopeptide Synthesis by Suzuki-Miyaura Couplings between Glycosyl Aryl Boronic Acids and Iodopeptides [J] . Guohua Chen, Xiangying Gu, Xin Wang, Protein and peptide letters . 2014,第10期

机译：糖基芳基硼酸和碘肽之间的铃木-Miyaura偶联合成新糖肽
2. Palladium-Catalyzed Suzuki-Miyaura Cross-Couplings of Sulfonyl Chlorides and Boronic Acids [J] . Srinivas Reddy Dubbaka, Pierre Vogel Organic letters . 2004,第1期

机译：钯催化的磺酰氯和硼酸的铃木-宫浦交叉偶联
3. Palladium-Catalyzed Suzuki-Miyaura Cross-Couplings of Sulfonyl Chlorides and Boronic Acids [J] . Srinivas Reddy Dubbaka, Pierre Vogel Organic letters . 2004,第1期

机译：钯催化的磺酰氯和硼酸的铃木-宫浦交叉偶联
4. Ruthenocenyl Phosphine Designed as Novel Class of Phosphine-Arene Ligand: Application to Suzuki-Miyaura Reaction of Electronically and Sterically Deactivated Aryl Halides with Aryl Boronic Acids [C] . Takashi Hoshi, Taichi Nakazawa, Toshio Suzuki Symposium on Organometallic Chemistry . 2006

机译：设计为新型膦 - 芳烃配体的钌烯基膦：用芳族硼酸的电子和空间去激活的芳基卤化物的铃木 - 咪糕的反应应用
5. Enantiospecific, regioselective Suzuki-Miyaura cross-couplings of secondary, allylic boronic esters. [D] . LaBine, Emily Judith. 2014

机译：对映体，区域选择性的仲烯丙基硼酸酯的Suzuki-Miyaura交叉偶联。
6. Axial shielding of Pd(II) complexes enables perfect stereoretention in Suzuki-Miyaura cross-coupling of Csp3 boronic acids [O] . Jonathan W. Lehmann, Ian T. Crouch, Daniel J. Blair, -1

机译：轴向屏蔽Pd（II）配合物可在Csp3硼酸的Suzuki-Miyaura交叉偶联中实现完美的立体保留
7. Palladium-Catalyzed Suzuki-Miyaura Cross-Couplings of Sulfonyl Chlorides and Boronic Acids [O] . -1

机译：钯催化的铃木 - 咪糕磺酰氯和硼酸的交叉联轴器

Immobilized boronic acid for Suzuki–Miyaura coupling: application to the generation of pharmacologically relevant molecules

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