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首页> 外文期刊>RSC Advances >Robust microfluidic construction of hybrid microfibers based on konjac glucomannan and their drug release performance
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Robust microfluidic construction of hybrid microfibers based on konjac glucomannan and their drug release performance

机译：基于魔芋葡甘露聚糖的混杂微纤维的稳健微流控结构及其药物释放性能

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The exploration of methods to produce a novel wound dressing with sustained drug release properties in ultrasmall scales is of great scientific and technological interest. Herein, we propose konjac glucomannan/polyvinylidene fluoride (KGM/PVDF) hybrid microfibers having hydrophilic and hydrophobic segments based on microfluidic-oriented core–sheath composite microfibers, where the KGM/PVDF hybrid microfibers are wrapped in situ in CH _(3) OH. The morphology of KGM/PVDF microfibers is uniform, smooth, and crack-free. Enrofloxacin (Enro) is loaded onto the microfibers as a representative cargo to test their release performance. The KGM/PVDF/Enro microfibers show sustained drug release performance (13 days), excellent heat resistance, antibacterial activity and promotion of wound healing. This study is an avenue toward the microfluidic design of hydrophilic/hydrophobic hybrid microfibers as wound dressings, and it will guide the development of next-generation wound dressing.
机译：探索生产具有超小尺度持续释药性能的新型伤口敷料的方法具有重大的科学技术意义。在此，我们基于微流体定向芯-皮复合微纤维，提出了具有亲水和疏水链段的魔芋葡甘露聚糖/聚偏二氟乙烯（KGM / PVDF）杂化微纤维，其中，KGM / PVDF杂化微纤维原位包裹在CH _（3）OH中。 KGM / PVDF超细纤维的形态均匀，光滑且无裂纹。将恩诺沙星（Enro）作为代表性货物装载到微纤维上，以测试其释放性能。 KGM / PVDF / Enro超细纤维显示出持续的药物释放性能（13天），出色的耐热性，抗菌活性并促进伤口愈合。这项研究为亲水/疏水杂化超细纤维作为伤口敷料的微流体设计提供了一条途径，并将指导下一代伤口敷料的发展。

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